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  1. Article

    Open Access

    Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis

    Dynamic alteration of DNA methylation leads to various human diseases, including nonalcoholic fatty liver disease (NAFLD). Although C-Maf-inducing protein (Cmip) has been reported to be associated with NAFLD, ...

    Jangho Lee, Ji-Hye Song, Jae-Ho Park, Min-Yu Chung… in Experimental & Molecular Medicine (2023)

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  2. Article

    Open Access

    ADAMTS-1: a novel target gene of an estrogen-induced transcription factor, EGR1, critical for embryo implantation in the mouse uterus

    Recently, we demonstrated that estrogen (E2) induces early growth response 1 (Egr1) to mediate its actions on the uterine epithelium by controlling progesterone receptor signaling for successful embryo implantati...

    Mira Park, So Hee Park, Hyunsun Park, Hye-Ryun Kim, Hyunjung J. Lim… in Cell & Bioscience (2021)

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  3. Article

    Open Access

    Secretory phospholipase A2-X (Pla2g10) is a novel progesterone receptor target gene exclusively induced in uterine luminal epithelium for uterine receptivity in mice

    Aberration of estrogen (E2) and/or progesterone (P4) signaling pathways affects expression of their target genes, which may lead to failure of embryo implantation and following pregnancy. Although many target gen...

    Hee Kyoung Park, So Hee Park, Miji Lee, Gyeong Ryeong Kim, Mira Park… in Cell & Bioscience (2020)

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  4. No Access

    Article

    Electroporation of AsCpf1/RNP at the Zygote Stage is an Efficient Genome Editing Method to Generate Knock-Out Mice Deficient in Leukemia Inhibitory Factor

    CRISPR/Cpf1 is a class II, type V RNA-guided endonuclease that is distinct from the type II CRISPR/Cas9 nuclease, widely used for genome editing. Cpf1 is a smaller and simpler endonuclease than Cas9, overcomin...

    Yeon Sun Kim, Gyeong Ryeong Kim, Mira Park… in Tissue Engineering and Regenerative Medici… (2020)

  5. No Access

    Article

    PCL/β-TCP Composite Scaffolds Exhibit Positive Osteogenic Differentiation with Mechanical Stimulation

    We investigated the use of Polycaprolactone (PCL)/ β-tricalcium phosphate (β-TCP) composites with applied mechanical stimulation as scaffold for bone tissue engineering. PCL-based three-dimensional (3D) struct...

    So Hee Park, Su A. Park, Yun Gyeong Kang… in Tissue Engineering and Regenerative Medici… (2017)

  6. Article

    Open Access

    Effects of mechanical stimulation on the reprogramming of somatic cells into human-induced pluripotent stem cells

    Mechanical stimuli play important roles in the proliferation and differentiation of adult stem cells. However, few studies on their effects on induced pluripotent stem cells (iPSCs) have been published.

    Young Mi Kim, Yun Gyeong Kang, So Hee Park, Myung-Kwan Han… in Stem Cell Research & Therapy (2017)

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  7. No Access

    Article

    물리적 인장 자극에 의한 줄기세포의 분화에 동반되는 미토콘드리아의 특성 변화에 관한 고찰

    Recent studies have confirmed that the direction of stem cell differentiation can be modulated by physical stimuli even without biochemical growth factors. This implies stem cells attribute their differentiati...

    Ji Won Shin, Hye Lim Kim, Yun Gyeong Kang… in Tissue Engineering and Regenerative Medici… (2015)

  8. No Access

    Article

    Effects of various patterns of intermittent hydrostatic pressure on the osteogenic differentiation of mesenchymal stem cells

    This study investigated the effects of intemittent hydrostatic pressure (IHP) patterns on the responses of mesenchymal stem cells (MSCs) such as osteogenic differentiation, proliferation and senescence. For th...

    Yun Gyeong Kang, M. V. Garcia, J. C. Marquez… in Tissue Engineering and Regenerative Medici… (2014)

  9. No Access

    Article

    Characterization of a hybrid bone substitute composed of polylactic acid tetrapod chips and hydroxyapatite powder

    This study evaluated a novel bone substitute composed of biodegradable polylactic acid (PLA) chips and hydroxyapatite (HA) powder. Using a microinjection molding technique, we manufactured tetrapod-shaped PLA ...

    So Hee Park, Sung-Hee Park, Dae Sung Park… in Tissue Engineering and Regenerative Medici… (2013)