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Article
Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host
Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are considered promiscuous because they cause disease across a range of host specie...
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Article
C13orf31 (FAMIN) is a central regulator of immunometabolic function
Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called ‘FAMIN’) in regulating macrophage fatty-acid oxidation a...
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Article
High-throughput phenoty** reveals expansive genetic and structural underpinnings of immune variation
By develo** a high-density murine immunophenoty** platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation ( ...
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Article
Open AccessIdentification of gut microbial species linked with disease variability in a widely used mouse model of colitis
Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous ...