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Article
C13orf31 (FAMIN) is a central regulator of immunometabolic function
Variants of the human gene C13orf31 (LACC1) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called ‘FAMIN’) in regulating macrophage fatty-acid oxidation a...
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Article
Adaptation of host transmission cycle during Clostridium difficile speciation
Bacterial speciation is a fundamental evolutionary process characterized by diverging genotypic and phenotypic properties. However, the selective forces that affect genetic adaptations and how they relate to t...
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Article
High-throughput phenoty** reveals expansive genetic and structural underpinnings of immune variation
By develo** a high-density murine immunophenoty** platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation ( ...
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Article
Open AccessLentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder characterised by recurrent and often life-threatening infections and hyperinflammation. It is caused by defects of the phag...