-
Article
Open AccessDNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is prevalent in the aging society. Despite body weight reduction, the prevalence of NAFLD has been increasing with aging for unknown reasons. Here, we investigate the ...
-
Article
Open AccessInfluence of thickness and strength on plastic instability in tailored steel structures
A mathematical model was intricately devised to explore the influence of continuous variations in thickness and mechanical properties on the performance of tailor rolled blanks (TRB) and tailor rolled tubes (T...
-
Article
Open AccessA method for extracting aquatic animal disease prevention and control events integrated with capsule network
Addressing the issue of long-tail event entity recognition in aquatic animal disease prevention and control, this paper proposes an event extraction method that integrates capsule networks. The method designs ...
-
Article
Open AccessIdentification of 1-Methylnicotinamide as a specific biomarker for the progression of cirrhosis to hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a prevalent malignant tumor, often arising from hepatitis induced by the hepatitis B virus (HBV) in China. However, effective biomarkers for early diagnosis are lacking, leadi...
-
Article
Research on the influence of laser process parameters on the quality of magnesium alloy laser cutting
A high-power fiber laser was used to cut AZ31B magnesium alloy. The effects of laser cutting speed, assisted air pressure, and defocus on cutting quality were studied systematically. Scanning electron microsco...
-
Article
Cross-ancestry genome-wide association studies of brain imaging phenotypes
Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely under-represented. Here, we conducted Chinese-alone and cross-ancest...
-
Article
A new bandwidth selection method for nonparametric modal regression based on generalized hyperbolic distributions
As a complement to standard mean and quantile regression, nonparametric modal regression has been broadly applied in various fields. By focusing on the most likely conditional value of Y given x, the nonparame...
-
Article
Antitumor effect of tubeimoside-I on murine colorectal cancers through PKM2-dependent pyroptosis and immunomodulation
Induction of cancer cell death is an established treatment strategy, but chemotherapy drug-mediated apoptosis can be evaded by many tumors. Pyroptosis is a type of inflammatory programmed cell death (PCD) that...
-
Article
Open AccessDe novo engineering riboflavin production Bacillus subtilis by overexpressing the downstream genes in the purine biosynthesis pathway
Bacillus subtilis is widely used in industrial-scale riboflavin production. Previous studies have shown that targeted mutagenesis of the ribulose 5-phosphate 3-epimerase in B. subtilis can significantly enhance r...
-
Article
Open AccessLongitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians
Obesity is a global public health concern linked to chronic diseases such as cardiovascular disease and type 2 diabetes (T2D). Emerging evidence suggests that epigenetic modifications, particularly DNA methyla...
-
Article
Open AccessMortality outcomes in diabetic metabolic dysfunction-associated fatty liver disease: non-obese versus obese individuals
The difference in the survival of obese patients and normal-weight/lean patients with diabetic MAFLD remains unclear. Therefore, we aimed to describe the long-term survival of individuals with diabetic MAFLD a...
-
Article
Open AccessGRAVEN: a database of teaching method that applies gestures to represent the neurosurgical approach’s blood vessels and nerves
In this era of rapid technological development, medical schools have had to use modern technology to enhance traditional teaching. Online teaching was preferred by many medical schools. However due to the comp...
-
Article
Open AccessInitiating PeriCBD to probe perinatal influences on neurodevelopment during 3–10 years in China
Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognit...
-
Article
Groundwater chemical evolution characteristics and human health risk assessment in Shicheng County, Jiangxi Province
Groundwater plays a pivotal role in the water resources of Shicheng County; however, the issue of excessive fluoride content in groundwater and its associated health risks often goes unnoticed. Groundwater ass...
-
Article
The applications of IL@MOFs for solid-state electrolytes in all-solid-state battery: a review
All-solid-state lithium batteries (ASSLBs) have aroused worldwide interests for their high safety and energy density. As known to all, solid-state electrolytes (SSEs) are one of the most important parts in ASS...
-
Article
Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits
Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA methylation changes in genetic predisposition, yet they have not been fully characterized in East Asians (EAs). Here ...
-
Article
Aspect-based sentiment analysis for fish diseases using a feature interaction model based on adversarial strategy
Aspect-based sentiment analysis has achieved many results in recent years, but most of the research focuses on goods, services, and topics. The research in the medical field is very limited. Considering the pr...
-
Article
Open AccessAgomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease
Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to variou...
-
Article
Open AccessAssociation of dietary calcium intake at dinner versus breakfast with cardiovascular disease in U.S. adults: the national health and nutrition examination survey, 2003–2018
Currently, it is still largely unknown whether the proportion of calcium intake at breakfast and dinner is associated with cardiovascular disease (CVD) in the general population.
-
Article
Open AccessLacto-ovo-vegetarian diet is inversely associated with the osteosarcopenia in older adults
Osteosarcopenia adversely affects the quality of life and physical health of older adults. We sought to explore the association between dietary patterns and osteosarcopenia in community-dwelling older adults.
