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  1. No Access

    Article

    SNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells

    Since being introduced globally as aspirin in 1899, acetylsalicylic acid has been widely used as an analgesic, anti-inflammation, anti-pyretic, and anti-thrombotic drug for years. Aspirin had been reported to ...

    Kher Hsin Chiow, Yingrou Tan, Rong Yuan Chua… in Cellular and Molecular Life Sciences (2012)

  2. Article

    A novel CARD containing splice-isoform of CIITA regulates nitric oxide synthesis in dendritic cells

    MHC class II expression is controlled mainly at transcriptional level by class II transactivator (CIITA), which is a non-DNA binding coactivator and serves as a master control factor for MHC class II genes exp...

    Dachuan Huang, Sylvia Lim, Rong Yuan Ray Chua, Hong Shi, Mah Lee Ng… in Protein & Cell (2010)

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    Article

    SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P

    The sorting nexin (SNX) protein family is implicated in regulating membrane traffic, but the mechanism is still unknown. We show that SNX3 is associated with the early endosome through a novel motif (PX domain...

    Yue Xu, Heinz Hortsman, Lifong Seet, Siew Heng Wong, Wan** Hong in Nature Cell Biology (2001)