37,036 Result(s)
-
Article
Recent Advancements in Fluid Dynamics: Drag Reduction, Lift Generation, Computational Fluid Dynamics, Turbulence Modelling, and Multiphase Flow
By improving the understanding of fluid behaviour and allowing the development of cutting-edge technologies that enhance fluid-related processes in various sectors, advances in fluid dynamics serve a crucial r...
-
Article
Open AccessElectron stochastic acceleration in laboratory-produced kinetic turbulent plasmas
The origin of energetic charged particles in universe remains an unresolved issue. Astronomical observations combined with simulations have provided insights into particle acceleration mechanisms, including ma...
-
Article
Open AccessA study of size threshold for cooling effect in urban parks and their cooling accessibility and equity
Rapid urbanization has led to increasingly prominent urban heat island phenomena and social inequality. It is urgent to quantify the threshold area of urban parks from multiple perspectives to maximize the coo...
-
Article
Open AccessDemethylation C–C coupling reaction facilitated by the repulsive Coulomb force between two cations
Carbon chain elongation (CCE) is normally carried out using either chemical catalysts or bioenzymes. Herein we demonstrate a catalyst-free approach to promote demethylation C–C coupling reactions for advanced ...
-
Article
Open AccessAsymmetric total synthesis of polycyclic xanthenes and discovery of a WalK activator active against MRSA
The development of new antibiotics continues to pose challenges, particularly considering the growing threat of multidrug-resistant Staphylococcus aureus. Structurally diverse natural products provide a promising...
-
Article
Open AccessPDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system
Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from current approaches, we devised a tunable strategy...
-
Article
Open AccessCholine consumption reduces CVD risk via body composition modification
Despite extensive research on the relationship between choline and cardiovascular disease (CVD), conflicting findings have been reported. We aim to investigate the relationship between choline and CVD. Our ana...
-
Article
Open AccessImmune cell landscapes are associated with high-grade serous ovarian cancer survival
High-grade serous ovarian cancer (HGSOC) is an aggressive disease known to develop resistance to chemotherapy. We investigated the prognostic significance of tumor cell states and potential mechanisms underlyi...
-
Article
Open AccessTherapeutic potential of the secreted Kazal-type serine protease inhibitor SPINK4 in colitis
Mucus injury associated with goblet cell (GC) depletion constitutes an early event in inflammatory bowel disease (IBD). Using single-cell sequencing to detect critical events in mucus dysfunction, we discover ...
-
Article
Open AccessNitrifying niche in estuaries is expanded by the plastisphere
The estuarine plastisphere, a novel ecological habitat in the Anthropocene, has garnered global concerns. Recent geochemical evidence has pointed out its potential role in influencing nitrogen biogeochemistry....
-
Article
Open AccessDynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
Adipose tissue plays critical roles in an individual’s aging process. In this research, we use single-nucleus RNA sequencing to create highly detailed transcriptional maps of subcutaneous adipose tissue and vi...
-
Article
Open AccessAuthor Correction: HDAC6, modulated by miR-206, promotes endometrial cancer progression through the PTEN/AKT/mTOR pathway
-
Article
Open AccessLong-term prediction modeling of shallow rockburst with small dataset based on machine learning
Rockburst present substantial hazards in both deep underground construction and shallow depths, underscoring the critical need for accurate prediction methods. This study addressed this need by collecting and ...
-
Article
Open AccessAssessing the extent and persistence of major crisis events in the crude oil market and economy: evidence from the past 30 years
This study investigates the extent and persistence of major crisis events in the crude oil market and economy and searches for general rules of event impact. Although the short-term effects of such crises may ...
-
Article
Open AccessAssociation of triglyceride glucose-body mass index with Alzheimer’s disease pathology, cognition and brain structure in non-demented people
The relationship between the triglyceride glucose-body mass index (TyG-BMI) index and Alzheimer’s disease (AD) pathology, cognition, and brain structure remains unclear. This study aimed to investigate these a...
-
Article
Open AccessSliding mode control strategy based on disturbance observer for permanent magnet in-wheel motor
A novel sliding mode control(NSMC) strategy combined with a fast terminal sliding mode observer(FTSMO) is suggested in this paper to solve the parameter variation issue of permanent magnet in-wheel motor(PMIWM...
-
Article
Open AccessThe road home: intimacy with parents, trust, and depression
Within the contemporary mental health discourse, the complex interplay of intimacy with parents, trust, and their collective impact on depression remains insufficiently explored, especially amid the merging of...
-
Article
Open AccessOptimizing high-temperature energy storage in tungsten bronze-structured ceramics via high-entropy strategy and bandgap engineering
As a vital material utilized in energy storage capacitors, dielectric ceramics have widespread applications in high-power pulse devices. However, the development of dielectric ceramics with both high energy de...
-
Article
Open AccessTRIM59 deficiency promotes M1 macrophage activation and inhibits colorectal cancer through the STAT1 signaling pathway
Tumor-associated macrophages play a crucial role in the tumor microenvironment. Tripartite motif 59 (TRIM59), a member of the tripartite motif (TRIM) family, is known to be associated with immunological diseas...
-
Article
Open AccessBi-directional context-aware network for the nested named entity recognition
The Span-based model can effectively capture the complex entity structure in the text, thus becoming the mainstream model for nested named entity recognition (Nested NER) tasks. However, traditional Span-based...