-
Article
Open AccessAnalysis of clinical characteristics of mismatch repair status in colorectal cancer: a multicenter retrospective study
Microsatellite instability (MSI) caused by DNA mismatch repair (MMR) deficiency is of great significance in the occurrence, diagnosis and treatment of colorectal cancer (CRC).
-
Article
Training with One2MultiSeq: CopyBART for social media keyphrase generation
Keyphrase generation, which can help people obtain key information from a long document (social media posts or scientific articles) in a short time, has made significant progress in recent years, especially fo...
-
Article
Whey Protein-Based High Internal Phase Emulsion Gel Characterization and Its Effect on the Textural and Melting Properties of Processed Cheese
Some undesirable physical characteristics of processed cheese due to insufficient fat emulsification have prompted extra ingredients to be added to compensate. Whey proteins offer promising nutritional and emu...
-
Article
Open AccessA single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning
Adipose tissue development begins in the fetal period, and continues to expand after birth. Dysregulation of adipose tissue during weaning may predispose individuals to lifelong metabolic disorders. However, t...
-
Article
Open AccessCumulative exposure to AHA Life's Essential 8 is associated with nonalcoholic fatty liver disease: a large cohort study
We aimed to explore the associations of baseline and cumulative cardiovascular health with nonalcoholic fatty liver disease (NAFLD) development and regression using the new Life’s Essential 8 score.
-
Article
Possible enrichment process of Cd in the Se-rich soil area of Lanshan District, Shandong Province, China
High cadmium (Cd) concentrations widely occured in selenium (Se)-rich soils, which has been an important obstacle in the usage of Se-rich soils. There is still no special information detailing the enrichment p...
-
Article
Open AccessCircZfp644-205 inhibits osteoblast differentiation and induces apoptosis of pre-osteoblasts via sponging miR-455-3p and promoting SMAD2 expression
Circular RNAs (circRNAs) are involved in the progression of osteoporosis; however, their impact on osteogenic differentiation has yet to be fully elucidated. In this study, we identified a novel circRNA known ...
-
Article
Open AccessAdvanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of atherosclerosis. Additionally, it has been demonstrated that receptor for advanced gl...
-
Article
An injectable, self-healable, and reusable PEDOT:PSS/PVA hydrogel patch electrode for epidermal electronics
Injectability empowers conductive hydrogels to transcend traditional limitations, unlocking a realm of possibilities for innovative medical, wearable, and therapeutic applications that can significantly enhanc...
-
Article
Investigation of Co–Mn–Ce Ternary Composite Oxide Catalyst for Low-Temperature Selective Catalytic Reduction of NOx with NH3
In this paper, the CoxMn1Cey composite oxide catalyst was synthesized by the co-precipitation method. The structure–activity relationship of the catalyst was analyzed by characterization methods such as XRD, Rama...
-
Article
Concurrent Assessment on Blood Lead in Young Children and Toy Lead in Shanghai
Since toys are potential sources of lead contamination for young children, we aim to explore potential correlations between blood-lead-levels (BLLs) of young children and toy-lead contamination using two concu...
-
Article
Deciphering site formation processes in lakeshore environments: a case study of early pleistocene site of Feiliang (Nihewan Basin, China)
Lakeshore environments often preserve a rich record of Pleistocene hominin evidence, and hence are promising vantage points from which to infer hominin evolutionary pathways. However, early Pleistocene sites f...
-
Article
DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression
Type 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N6-methyladenosine (m6A) of IGF1R remains unclear. Here, we reveal a role for ...
-
Article
Open AccessNotch signaling pathway in cancer: from mechanistic insights to targeted therapies
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are tran...
-
Article
Effects of Psychological Resilience on Online Learning Performance and Satisfaction Among Undergraduates: The Mediating Role of Academic Burnout
Online learning has accentuated the role and interaction of numerous educational and psychological factors among students, especially undergraduates. Psychological resilience, as an evaluative factor of mental...
-
Article
Electronic structure engineering of single atomic sites by plasmon-induced hot electrons for highly efficient and selective photocatalysis
Single atom (SA) catalysts have achieved great success on highly selective heterogeneous catalysis due to their abundant and homogeneous active sites. The electronic structures of these active sites, restraine...
-
Article
Open AccesslncRNA Oip5-as1 inhibits excessive mitochondrial fission in myocardial ischemia/reperfusion injury by modulating DRP1 phosphorylation
Aberrant mitochondrial fission, a critical pathological event underlying myocardial ischemia/reperfusion (MI/R) injury, has emerged as a potential therapeutic target. The long non-coding RNA (lncRNA) Oip5-as1 ...
-
Article
Open AccessA simple and highly sensitive LC–MS workflow for characterization and quantification of ADC cleavable payloads
Antibody–drug conjugates (ADC) payloads are cleavable drugs that act as the warhead to exert an ADC’s cytotoxic effects on cancer cells intracellularly. A simple and highly sensitive workflow is developed and ...
-
Article
Research on Identification Method of Cable Cross-Sectional Loss Rates Based on Multiple Magnetic Characteristic Indicators
The identification of cross-sectional loss in cables due to corrosion is crucial for evaluating the remaining strength of bridge cables. To accurately determine the cross-sectional loss rate, this paper derive...
-
Article
Open AccessTranscriptomic study of the role of MeFtsZ2-1 in pigment accumulation in cassava leaves
MeFtsZ2-1 is a key gene for plant plastid division, but the mechanism by which MeFtsZ2-1 affects pigment accumulation in cassava (Manihot esculenta Crantz) through plastids remains unclear. We found that MeFtsZ2-...
