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  1. No Access

    Article

    Current approaches to genomic deep learning struggle to fully capture human genetic variation

    Deep learning shows promise for predicting gene expression levels from DNA sequences. However, recent studies show that current state-of-the-art models struggle to accurately characterize expression variation ...

    Ziqi Tang, Shushan Toneyan, Peter K. Koo in Nature Genetics (2023)

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    Article

    ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation

    The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the transcriptional repressor ETV6 as a uniqu...

    Yuan Gao, Xue-Yan He, **aoli S. Wu, Yu-Han Huang, Shushan Toneyan… in Nature Cell Biology (2023)