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  1. Article

    Open Access

    EvoAug: improving generalization and interpretability of genomic deep neural networks with evolution-inspired data augmentations

    Deep neural networks (DNNs) hold promise for functional genomics prediction, but their generalization capability may be limited by the amount of available data. To address this, we propose EvoAug, a suite of e...

    Nicholas Keone Lee, Ziqi Tang, Shushan Toneyan, Peter K. Koo in Genome Biology (2023)

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    Article

    ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation

    The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the transcriptional repressor ETV6 as a uniqu...

    Yuan Gao, Xue-Yan He, **aoli S. Wu, Yu-Han Huang, Shushan Toneyan… in Nature Cell Biology (2023)