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Article
Open AccessDecreased levels of PTCSC3 promote the deterioration of prostate cancer and affect the prognostic outcome of patients through sponge miR-182-5p
Prostate cancer, characterized by its insidious onset and short overall survival, and has seen a rise in incidence over recent decades. This study aims to investigate the expression and molecular mechanism of ...
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Article
Open AccessMachine learning methods for adult OSAHS risk prediction
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a common disease that can cause multiple organ damage in the whole body. Our aim was to use machine learning (ML) to build an independent polysomnography (P...
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Article
Open AccessTORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors
Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) is an effective therapeutic target for diseases such as cancer, diabetes, aging, and neurodegeneration. However, an efficient tool for monitoring...
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Article
Open AccessUnveiling the hidden role of the interaction between CD36 and FcγRIIb: implications for autoimmune disorders
The role of the scavenger receptor CD36 in cell metabolism and the immune response has been investigated mainly in macrophages, dendritic cells, and T cells. However, its involvement in B cells has not been co...
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Article
Open AccessVEGFR2 blockade inhibits glioblastoma cell proliferation by enhancing mitochondrial biogenesis
Glioblastoma is an aggressive brain tumor linked to significant angiogenesis and poor prognosis. Anti-angiogenic therapies with vascular endothelial growth factor receptor 2 (VEGFR2) inhibition have been inves...
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Article
Open AccessDSCAM-AS1 promotes the development of prostate cancer
The purpose of this study was to investigate the role of lncRNA DSCAM-AS1 in prostate cancer to find new therapeutic targets and promote the research progress of prostate cancer.
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Article
Open AccessUsing social network analysis to investigate mathematical connections in U.S. and Chinese textbook problems
Textbooks, as potentially implemented curricula, play an important role in supporting classroom teaching and learning. Mathematical connections, one of the essential and hot topics advocated in mathematics edu...
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Article
Open AccessBaseline symptom-related white matter tracts predict individualized treatment response to 12-week antipsychotic monotherapies in first-episode schizophrenia
There is significant heterogeneity in individual responses to antipsychotic drugs, but there is no reliable predictor of antipsychotics response in first-episode psychosis. This study aimed to investigate whet...
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Article
Female reproductive health during the COVID-19 pandemic: latest evidence and understanding
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has imposed a heavy burden on medical systems. In addition to the respiratory s...
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Article
Open AccessSIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1
Endothelial–mesenchymal transition (EndMT) plays a crucial role in promoting myocardial fibrosis and exacerbating cardiac dysfunction. Dapagliflozin (DAPA) is a sodium–glucose-linked transporter 2 (SGLT-2) inh...
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Article
Open AccessZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury
Mitochondria dysfunction contributes to acute liver injuries, and mitochondrial regulators, such as PGC-1α and MCJ, affect liver regeneration. Therefore, identification of mitochondrial modulators may pave the...
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Article
Open AccessHighly sensitive flexible heat flux sensor based on a microhole array for ultralow to high temperatures
With the growing demand for thermal management of electronic devices, cooling of high-precision instruments, and biological cryopreservation, heat flux measurement of complex surfaces and at ultralow temperatu...
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Article
Open AccessTeachers’ perceptions of less successfully organized professional development practices in mathematics: A study of nine secondary schools in Shanghai, China
Professional development (PD) for mathematics teachers in China, especially in Shanghai, has received growing international attention. However, most of available research concerning Chinese PD has focused on s...
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Article
Electrospun Nanocomposite Fibrous Membranes for Sustainable Face Mask Based on Triboelectric Nanogenerator with High Air Filtration Efficiency
Air pollution caused by the rapid development of industry has always been a great issue to the environment and human being’s health. However, the efficient and persistent filtration to PM0.3 remains a great chall...
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Article
Open AccessAngulation error assessment for the trajectory in the anteroposterior and lateral fluoroscopic views during percutaneous endoscopic transforaminal lumbar discectomy
Anteroposterior (AP) and lateral fluoroscopies are often used to evaluate the intraoperative location and angulation of the trajectory in percutaneous endoscopic transforaminal lumbar discectomy (PETLD). Altho...
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Article
Open AccessP38 MAPK activated ADAM17 mediates ACE2 shedding and promotes cardiac remodeling and heart failure after myocardial infarction
Heart failure (HF) after myocardial infarction (MI) is a prevalent disease with a poor prognosis. Relieving pathological cardiac remodeling and preserving cardiac function is a critical link in the treatment o...
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Article
Open AccessIdentification and analysis of the genetic integrity of different types of rice resources through SSR markers
Seed aging is the key factor leading to the loss of genetic integrity. In this study, the seeds of Dongxiang wild rice, **anggu, 9194 and Nipponbare were kept in a plant incubator with constant temperature and...
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Chapter and Conference Paper
Seepage Analysis of Drainage Decompression in Slo** Basement
The accidents of bottom floor cracking occur on underground structure due to uplift pressure. Especially in the southern rainy area, super large buildings on slope with high underground water level are in a co...
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Article
Open AccessThe effect of prolonged holding time on the mechanical property and microstructural property of lithium disilicate glass-ceramic
Repeat firing produces uncertainty about stabilizing lithium disilicate glass-ceramic (LDGC) material properties, even though prolonged holding time can enhance the mechanical property of LDGC during a single ...
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Article
Open AccessPublisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
