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Article
Open AccessHigh expression of SRSF1 facilitates osteosarcoma progression and unveils its potential mechanisms
SRSF1, a member of Serine/Arginine-Rich Splicing Factors (SRSFs), has been observed to significantly influence cancer progression. However, the precise role of SRSF1 in osteosarcoma (OS) remains unclear. This ...
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Article
Open AccessEffects of mindfulness on depression in college students: mediating role of psychological resilience and moderating role of gender
A questionnaire was administered to 936 college students to investigate the mediating effect of psychological resilience in the association between mindfulness and college student depression, as well as the mo...
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Article
Open AccessIdentification of sulfur metabolism-related gene signature in osteoarthritis and TM9SF2’s sustenance effect on M2 macrophages' phagocytic activity
Osteoarthritis (OA) is a chronic and low-grade inflammatory disease associated with metabolism disorder and multiple cell death types in the synovial tissues. Sulfur metabolism has not been studied in OA.
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Article
Open AccessA chain mediation model reveals the association between mindfulness and depression of college students
The study aims to explore the relationship among mindfulness, depression, meaning in life (MIL) and psychological resilience (PR), and verify whether MIL and PR have a chain mediating effect between mindfulnes...
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Article
Open AccessLong-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years
This study aimed to investigate the long-term effect of vitamin D supplementation compared to placebo over 5 years in participants with knee osteoarthritis (OA). We also aimed to describe the effect of maintai...
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Article
Open AccessNovel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis
Atherosclerosis is a maladaptive chronic inflammatory disease, which remains the leading cause of death worldwide. The NLRP3 inflammasome constitutes a major driver of atherosclerosis, yet the mechanism of act...
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Article
Open AccessExcessive mechanical stress-induced intervertebral disc degeneration is related to Piezo1 overexpression triggering the imbalance of autophagy/apoptosis in human nucleus pulpous
Mechanical stress plays a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). The mechanosensitive Piezo1 ion channel can sense the changes in mechanical stress and convert the mechani...
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Article
Open AccessCircadian humidity fluctuation induced capillary flow for sustainable mobile energy
Circadian humidity fluctuation is an important factor that affects human life all over the world. Here we show that spherical cap-shaped ionic liquid drops sitting on nanowire array are able to continuously ou...
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Article
Open AccessEvaluating different energized fracturing fluids using an integrated equation-of-state compositional hydraulic fracturing and reservoir simulator
Horizontal wells are often drilled and hydraulically fractured in tight reservoirs to produce hydrocarbons or heat. Different fracturing fluids such as slick water, gas, foam, gel, or a combination can be used...
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Article
Open AccessInactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth
EGLN3 is critically important for growth of various cancers including lung cancer. However, virtually nothing is known about the role and mechanism for EGLN3 hydroxylase activity in cancers. EGLN3 catalyzes th...
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Article
Critical adhesion areas of cells on micro-nanopatterns
Cell adhesion to extracellular matrices (ECM) is critical to physiological and pathological processes as well as biomedical and biotechnological applications. It has been known that a cell can adhere on an adh...
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Article
Open AccessThe role of XBP-1-mediated unfolded protein response in colorectal cancer progression-a regulatory mechanism associated with lncRNA-miRNA-mRNA network
We aim to identify the expression and analyze the molecular action of dysregulated lncRNA-miRNA mediated by XBP-1 in colorectal cancer (CRC).
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Article
Open AccessDepression in patients with knee osteoarthritis: risk factors and associations with joint symptoms
To describe demographic and clinical factors associated with the presence and incidence of depression and explore the temporal relationship between depression and joint symptoms in patients with symptomatic kn...
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Article
Open AccessThe impact and distinction of ‘lipid healthy but obese’ and ‘lipid abnormal but not obese’ phenotypes on lumbar disc degeneration in Chinese
Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-...
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Article
Open AccessComparison of ED95 of Butorphanol and Sufentanil for gastrointestinal endoscopy sedation: a randomized controlled trial
Butorphanol, a synthetic opioid partial agonist analgesic, has been widely used to control perioperative pain. However, the ideal dose and availability of butorphanol for gastrointestinal (GI) endoscopy are no...
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Article
Open AccessMicro-/nano-voids guided two-stage film cracking on bioinspired assemblies for high-performance electronics
Current metal film-based electronics, while sensitive to external stretching, typically fail via uncontrolled cracking under a relatively small strain (~30%), which restricts their practical applications. To a...
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Article
Correction to: Liaoning Score for Prediction of Esophageal Varices in Cirrhotic Patients Who Had Never Undergone Endoscopy: A Multicenter Cross-Sectional Study in Liaoning Province, China
Unfortunately, the fourteenth author’s name was incorrectly published in the Original Article. The correct author name is Cen Hong.
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Article
Open AccessMRI-detected osteophytes of the knee: natural history and structural correlates of change
The natural history of semi-quantitative magnetic resonance imaging (MRI)-detected osteophytes (MRI-detected OPs) has not been described and it is unknown whether knee structural abnormalities can predict MRI-...
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Article
Open AccessResponse to olaparib in metastatic castration-resistant prostate cancer with germline BRCA2 mutation: a case report
Prostate cancer is a heterogeneous disease, meaning patients would benefit from different treatment strategies based on their molecular stratification. In recent years, several genomic studies have identified ...
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Article
Open AccessAssociations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study
Associations between adipokines and bone mineral density (BMD) in knee osteoarthritis (OA) remain indistinct. The aim of this study was to investigate the cross-sectional associations between serum levels of a...
