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Article
Mesenchymal stem cells and their extracellular vesicles in bone and joint diseases: targeting the NLRP3 inflammasome
The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a cytosolic multi-subunit protein complex, and recent studies have demonstrated the vital ro...
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Article
Open AccessDNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility
DNA replication in differentiated cells follows a defined program, but when and how it is established during mammalian development is not known. Here we show using single-cell sequencing, that late replicating...
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Article
Open AccessDeciphering the role of zinc homeostasis in the tumor microenvironment and prognosis of prostate cancer
Dysregulation of zinc homeostasis is widely recognized as a hallmark feature of prostate cancer (PCa) based on the compelling clinical and experimental evidence. Nevertheless, the implications of zinc dyshomeo...
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Article
28-day compressive strength prediction utilizing a radial basis function model incorporating meta-heuristic algorithms
The construction industry's swift manufacturing of building materials has played a pivotal role in environmental degradation worldwide. Researchers are now directing more focus towards investigating the enviro...
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Article
Open AccessUSP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase
Radioresistance is a key clinical constraint on the efficacy of radiotherapy in lung cancer patients. REV1 DNA directed polymerase (REV1) plays an important role in repairing DNA damage and maintaining genomic...
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Article
Open AccessAn integrated cofactor and co-substrate recycling pathway for the biosynthesis of 1,5-pentanediol
1,5-pentanediol (1,5-PDO) is a linear diol with an odd number of methylene groups, which is an important raw material for polyurethane production. In recent years, the chemical methods have been predominantly ...
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Article
Groundwater chemical evolution characteristics and human health risk assessment in Shicheng County, Jiangxi Province
Groundwater plays a pivotal role in the water resources of Shicheng County; however, the issue of excessive fluoride content in groundwater and its associated health risks often goes unnoticed. Groundwater ass...
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Article
A deep reinforcement learning approach incorporating genetic algorithm for missile path planning
The flight path planning of the missile is important in long-range air-to-ground strike missions. Constraints about missile guidance and guidance handover are considered, and path planning is required to confo...
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Article
Open AccessLow-cost dual-energy CBCT by spectral filtration of a dual focal spot X-ray source
Dual-energy cone beam computed tomography (DE-CBCT) has been shown to provide more information and improve performance compared to a conventional single energy spectrum CBCT. Here we report a low-cost DE-CBCT ...
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Article
Open AccessA study on expression recognition based on improved mobilenetV2 network
This paper proposes an improved strategy for the MobileNetV2 neural network(I-MobileNetV2) in response to problems such as large parameter quantities in existing deep convolutional neural networks and the shor...
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Article
Casting light on the dark side: unveiling the dual-edged effect of unethical pro-organizational behavior in ethical climate
This study examines the dual-edged sword effect of unethical pro-organizational behavior (UPB) by considering employees' participation in UPB and its impact on work engagement and burnout. Drawing on Appraisal...
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Article
Improved remote sensing image target detection based on YOLOv7
Remote sensing images are taken at high altitude from above, with complex spatial scenes of images and a large number of target types. The detection of image targets on large scale remote sensing images suffer...
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Article
Open AccessPrognostic value of measurement of myocardial extracellular volume using dual-energy CT in heart failure with preserved ejection fraction
Diffuse myocardial fibrosis is associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Dual-energy CT (DECT) can noninvasively assess myocardial fibrosis by quantification o...
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Article
A Novel AC Side Four-Switch Power Decoupling Circuit for Single-Phase Inverter
In single-phase inverter, the output voltage and current are both sinusoidal quantities with angular frequency ω. Thus, the instantaneous output power oscillates at angular frequency 2ω, which cause secondly ripp...
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Article
Open AccessCDKL1 potentiates the antitumor efficacy of radioimmunotherapy by binding to transcription factor YBX1 and blocking PD-L1 expression in lung cancer
The evasion of the immune response by tumor cells through programmed death-ligand 1 (PD-L1) has been identified as a factor contributing to resistance to radioimmunotherapy in lung cancer patients. However, th...
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Article
Rural human settlement environment improvement: process, status and China’s sample
China's victory over poverty is globally felt, significantly contributing to global poverty reduction. China has comprehensively promoted implementation the great project of improving rural human settlement en...
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Article
Selenium Deficiency Causes Iron Death and Inflammatory Injury Through Oxidative Stress in the Mice Gastric Mucosa
Selenium (Se) is a trace element essential for the maintenance of normal physiological functions in living organisms. Oxidative stress is a state in which there is an imbalance between oxidative and antioxidan...
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Article
Digital twin-driven design for elevator fairings via multi-objective optimization
Traditional geometry optimization of elevator fairings is only based on computational fluid dynamics simulations to find optimal structure parameters, and a large volume of data generated during the elevator o...
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Article
Open AccessImproving the accuracy of bone mineral density using a multisource CBCT
Multisource cone beam computed tomography CBCT (ms-CBCT) has been shown to overcome some of the inherent limitations of a conventional CBCT. The purpose of this study was to evaluate the accuracy of ms-CBCT fo...
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Article
Synthesis of rhodium catalyst [Rh(cod)(TTT)2] with amino group ligand and its catalytic performance for phenylacetylene polymerization
A new rhodium complex [Rh(cod)(TTT)2] was synthesized by [Rh(cod)Cl]2 as a precursor, and 4,4',4''-(1,3,5-triazine-2,4,6-triyl)trianiline (TTT) as a ligand. Its structure was verified by 1H and 13C NMR. The resul...
