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  1. No Access

    Article

    Clinical Association Between Pharmacogenomics and Adverse Drug Reactions

    Adverse drug reactions (ADRs) are a major public health concern and cause significant patient morbidity and mortality. Pharmacogenomics is the study of how genetic polymorphisms affect an individual’s response...

    Zhi-Wei Zhou, **ao-Wu Chen, Kevin B. Sneed, Yin-Xue Yang, Xueji Zhang, Zhi-Xu He… in Drugs (2015)

  2. Article

    Efficacy of a Therapeutic Vaccine Using Mutated β-amyloid Sensitized Dendritic Cells in Alzheimer’s Mice

    Despite FDA suspension of Elan’s AN-1792 amyloid beta (Aβ) vaccine in phase IIb clinical trials, the implications of this study are the guiding principles for contemporary anti-Aβ immunotherapy against Alzheim...

    Zhongqiu Luo, Jialin Li, Neel R. Nabar, **aoyang Lin… in Journal of Neuroimmune Pharmacology (2012)

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  3. No Access

    Article

    Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

    Part I of this article discussed the potential functional importance of genetic mutations and alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 polymorphisms on the clearance of and res...

    Shu-Feng Zhou in Clinical Pharmacokinetics (2009)

  4. No Access

    Article

    Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance

    Cytochrome P450 (CYP) 2D6 is one of the most investigated CYPs in relation to genetic polymorphism, but accounts for only a small percentage of all hepatic CYPs (∼2–4%). There is a large interindividual variat...

    Shu-Feng Zhou in Clinical Pharmacokinetics (2009)

  5. No Access

    Article

    Insights into the Substrate Specificity, Inhibitors, Regulation, and Polymorphisms and the Clinical Impact of Human Cytochrome P450 1A2

    Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine, tizanidine, and theophylline), a number of procarcinogens (e.g. benzo[a]pyre...

    Shu-Feng Zhou, Li-** Yang, Zhi-Wei Zhou, Ya-He Liu, Eli Chan in The AAPS Journal (2009)

  6. No Access

    Article

    Prediction of Deleterious Non-synonymous Single-Nucleotide Polymorphisms of Human Uridine Diphosphate Glucuronosyltransferase Genes

    UDP glucuronosyltransferases (UGTs) are an important class of Phase II enzymes involved in the metabolism and detoxification of numerous xenobiotics including therapeutic drugs and endogenous compounds (e.g. b...

    Yuan Ming Di, Eli Chan, Ming Qian Wei, Jun-** Liu, Shu-Feng Zhou in The AAPS Journal (2009)

  7. No Access

    Article

    Angiotensin II upregulates Toll-like receptor 4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells

    Activation of Toll-like receptor 4 (TLR4) in peritoneal mesothelial cells by endotoxin contributes to peritoneal inflammation and fibrosis. Here we investigated TLR4 expression induced by angiotensin II (Ang I...

    Jun Wu, **ao Yang, Yun-Fang Zhang, Shu-Feng Zhou, Rui Zhang… in Inflammation Research (2009)

  8. No Access

    Article

    Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat

    SYUIQ-5, a novel telomerase inhibitor, has demonstrated antitumor activity in nude mouse studies. The objective of the present study was to examine the metabolism and pharmacokinetics of SYUIQ-5 in rats. The p...

    Qi-Biao Su, Fan He, Xue-Ding Wang, Su Guan, Zhi-Yong **e… in Investigational New Drugs (2008)

  9. No Access

    Article

    Role of P-glycoprotein in Limiting the Brain Penetration of Glabridin, An Active Isoflavan from the Root of Glycyrrhiza glabra

    Glabridin is a major active constituent of Glycyrrhiza glabra which is commonly used in the treatment of cardiovascular and central nervous system (CNS) diseases. Recently, we have found that glabridin is a subst...

    **-Yong Yu, Shu-Guang Lin, Zhi-Wei Zhou, **ao Chen, Jun Liang… in Pharmaceutical Research (2007)

  10. Article

    Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations

    Srinivasa Rao Jada, Shu **aochen, Liu Yan Yan… in European Journal of Clinical Pharmacology (2007)

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  11. No Access

    Article

    Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations

    The aim of this study was to characterize the population frequency of SLCO1B1 polymorphic variants in three distinct healthy Asian populations, namely Chinese (n = 100), Malay (n = 100) and Indian (n = 100), and ...

    Srinivasa Rao Jada, Shu **aochen, Liu Yan Yan… in European Journal of Clinical Pharmacology (2007)

  12. No Access

    Article

    Intra- and Inter-ethnic Differences in the Allele Frequencies of Cytochrome P450 2B6 Gene in Chinese

    This study aimed to investigate the allele frequencies of CYP2B6 gene in 193 Han Chinese and compared with 91 Uygur Chinese. Five single nucleotide polymorphisms of CYP2B6, 64C>T, 516G>T, 777C>A, 785A>G and 1459C...

    Su Guan, Min Huang, **n Li, **ao Chen, Eli Chan, Shu-Feng Zhou in Pharmaceutical Research (2006)

  13. No Access

    Article

    Gene mutation of thiopurine S-methyltransferase in Uygur Chinese

    This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese.

    Jian-** Zhang, Yong-Yuan Guan, An-Long Xu… in European Journal of Clinical Pharmacology (2004)