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  1. No Access

    Article

    Insights into the Substrate Specificity, Inhibitors, Regulation, and Polymorphisms and the Clinical Impact of Human Cytochrome P450 1A2

    Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine, tizanidine, and theophylline), a number of procarcinogens (e.g. benzo[a]pyre...

    Shu-Feng Zhou, Li-** Yang, Zhi-Wei Zhou, Ya-He Liu, Eli Chan in The AAPS Journal (2009)

  2. No Access

    Article

    Prediction of Deleterious Non-synonymous Single-Nucleotide Polymorphisms of Human Uridine Diphosphate Glucuronosyltransferase Genes

    UDP glucuronosyltransferases (UGTs) are an important class of Phase II enzymes involved in the metabolism and detoxification of numerous xenobiotics including therapeutic drugs and endogenous compounds (e.g. b...

    Yuan Ming Di, Eli Chan, Ming Qian Wei, Jun-** Liu, Shu-Feng Zhou in The AAPS Journal (2009)

  3. No Access

    Article

    Role of P-glycoprotein in Limiting the Brain Penetration of Glabridin, An Active Isoflavan from the Root of Glycyrrhiza glabra

    Glabridin is a major active constituent of Glycyrrhiza glabra which is commonly used in the treatment of cardiovascular and central nervous system (CNS) diseases. Recently, we have found that glabridin is a subst...

    **-Yong Yu, Shu-Guang Lin, Zhi-Wei Zhou, **ao Chen, Jun Liang… in Pharmaceutical Research (2007)

  4. No Access

    Article

    Intra- and Inter-ethnic Differences in the Allele Frequencies of Cytochrome P450 2B6 Gene in Chinese

    This study aimed to investigate the allele frequencies of CYP2B6 gene in 193 Han Chinese and compared with 91 Uygur Chinese. Five single nucleotide polymorphisms of CYP2B6, 64C>T, 516G>T, 777C>A, 785A>G and 1459C...

    Su Guan, Min Huang, **n Li, **ao Chen, Eli Chan, Shu-Feng Zhou in Pharmaceutical Research (2006)