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  1. Article

    Open Access

    Transcriptomic analysis of the effects of Toll-like receptor 4 and its ligands on the gene expression network of hepatic stellate cells

    Intact Toll-like receptor 4 (TLR4) has been identified in hepatic stellate cells (HSCs), the primary fibrogenic cell type in liver. Here, we investigated the impact of TLR4 signaling on the gene expression net...

    Yangyang Ouyang, **sheng Guo, Chenzhao Lin, Jie Lin… in Fibrogenesis & Tissue Repair (2016)

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  2. Article

    Open Access

    HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression

    Esophageal squamous cell carcinoma (ESCC) remains one of the most common malignancies in China and has a high metastasis rate and poor prognosis. Cancer-associated fibroblasts (CAFs), a prominent component of ...

    Xuanling Du, Qi** Xu, Duyi Pan, Dongke Xu, Baolin Niu… in Cell Death & Disease (2019)

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  3. No Access

    Article

    Knockdown of TRIM15 inhibits the activation of hepatic stellate cells

    Liver fibrosis is a global public health problem, and the activation of hepatic stellate cells (HSCs) is the main driving force for liver fibrosis. However, the activation mechanism of HSCs is still not fully ...

    Junpei Zhang, Yin Chen, Yi Tian, Shiyao Chen, Hailing Liu in Journal of Molecular Histology (2021)

  4. No Access

    Article

    SREBF2 triggers endoplasmic reticulum stress and Bax dysregulation to promote lipopolysaccharide-induced endothelial cell injury

    An increased lipopolysaccharide (LPS) level in patients with cirrhosis induced the dysregulation of sterol regulatory element–binding transcription factor 2 (SREBF2), which participated in the modulation of tu...

    Gang Dong, **aoquan Huang, Ling Wu, Siyu Jiang, Qintian Tan… in Cell Biology and Toxicology (2022)