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Article
Open AccessEffect of interleukin-1 antagonist on growth of children with colchicine resistant or intolerant FMF
Familial Mediterranean Fever (FMF) is the most common monogentic autoinflammatory disease. FMF results from mutations in MEFV, which lead to a pro-inflammatory state and increased production of Interleukin 1 beta...
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Article
Open AccessColchicine treatment can be discontinued in a selected group of pediatric FMF patients
Familial Mediterranean Fever (FMF) patients are required to adhere to a life-long treatment with colchicine, primarily for preventing amyloidosis. As some patients may be asymptomatic for long periods of time,...
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Article
Open AccessWhole exome sequencing in childhood-onset lupus frequently detects single gene etiologies
Systemic lupus erythematosus (SLE) comprise a diverse range of clinical manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in humans have been identified. In the clinical se...