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3 Result(s)

within Shin-ichi Miyamoto Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter English Remove this filter

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  1. Article

    Open Access

    Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium

    Acetaldehyde is an ethanol-derived definite carcinogen that causes oesophageal squamous cell carcinoma (ESCC). Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that eliminates acetaldehyde and impairment of AL...

    Yusuke Amanuma, Shinya Ohashi, Yoshiro Itatani, Mihoko Tsurumaki… in Scientific Reports (2015)

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  2. Article

    Open Access

    Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma

    Epidermal growth factor receptor (EGFR) is a key molecule in the pathophysiology of oesophageal squamous cell carcinoma (OSCC). However, EGFR-targeted agents such as anti-EGFR antibody or tyrosine kinase inhib...

    Osamu Kikuchi, Shinya Ohashi, Tomohisa Horibe, Masayuki Kohno… in Scientific Reports (2016)

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  3. No Access

    Article

    Age-related remodelling of oesophageal epithelia by mutated cancer drivers

    Clonal expansion in aged normal tissues has been implicated in the development of cancer. However, the chronology and risk dependence of the expansion are poorly understood. Here we intensively sequence 682 mi...

    Akira Yokoyama, Nobuyuki Kakiuchi, Tetsuichi Yoshizato, Yasuhito Nannya… in Nature (2019)