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Article
Principle of designing slope compensation in PFC Boost converter
Due to wide input fluctuation with line frequency of 50 Hz, power-factor-correction (PFC) Boost converters tend to exhibit fast-scale instability over time domain. The traditional remedy is to impose slope com...
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Article
The anti-tumor effect of p53 gene-loaded hydroxyapatite nanoparticles in vitro and in vivo
This research focused on anti-tumor effect of pEGFP-C1-p53 (p53) gene-loaded hydroxyapatite (HAp) nanoparticles in vitro and in vivo. Four kinds of HAp nanoparticles, spherical HAp nanoparticles (S-HAp, diamet...
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Article
Embelin Sensitizes Acute Myeloid Leukemia Cells to TRAIL through XIAP Inhibition and NF-κB Inactivation
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows promising result in cancer therapy and induces apoptosis in a wide variety of tumor cells, without causing toxicity to normal cells. Howeve...
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Article
Open AccessPressure induced metallization with absence of structural transition in layered molybdenum diselenide
Layered transition-metal dichalcogenides have emerged as exciting material systems with atomically thin geometries and unique electronic properties. Pressure is a powerful tool for continuously tuning their cr...
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Article
Open AccessSignature of a polyamorphic transition in the THz spectrum of vitreous GeO2
The THz spectrum of density fluctuations, S(Q, ω), of vitreous GeO2 at ambient temperature was measured by inelastic x-ray scattering from ambient pressure up to pressures well beyond that of the known α-quartz t...
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Article
Open AccessCombined expression of miR-34a and Smac mediated by oncolytic vaccinia virus synergistically promote anti-tumor effects in Multiple Myeloma
Despite great progress made in the treatment of multiple myeloma (MM), it is still incurable. Promising phase II clinical results have been reported recently for oncolytic vaccinia virus (OVV) clinic therapeut...
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Chapter and Conference Paper
Apriori Algorithm-Based Association Rules of Event Language Expression Discovery
Event is the basic unit of knowledge representation, when human beings communicate with each other. Although event is objective in the real world, when it is described by voice, characters and other means, eve...
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Chapter and Conference Paper
Frequent Subtree-Based Event Language Expression Pattern Discovery
Event language expression plays an important role in the event ontology. Event language expression patterns are the part of the event language expression, which indicate the customary habits when human describ...
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Article
Open AccessA review on the advances and challenges of immunotherapy for head and neck cancer
Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide. Due to the interaction of tumor cells...
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Article
Open AccessNanocarriers surface engineered with cell membranes for cancer targeted chemotherapy
Inspired by nature, the biomimetic approach has been incorporated into drug nanocarriers for cancer targeted chemotherapy. The nanocarriers are cloaked in cell membranes, which enables them to incorporate the ...
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Article
Open AccessCD19-targeted BiTE expression by an oncolytic vaccinia virus significantly augments therapeutic efficacy against B-cell lymphoma
Immunotherapy with CD19-targeting bispecific T-cell engagers (CD19BiTEs) has demonstrated highly effective killing of cancer cells in patients with precursor acute lymphoblastic leukemia and non-Hodgkin’s lymp...
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Article
Open AccessThe correlation of fibrinogen-like protein-1 expression with the progression and prognosis of hepatocellular carcinoma
Fibrinogen-like-protein 1 (FGL1), a member of the fibrinogen-related protein (FREP) family, is a major ligand of the immune inhibitory receptor lymphocyte-activation gene 3 (LAG-3). While FGL1 is strongly impl...
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Article
Open AccessCombination therapy with oncolytic viruses and immune checkpoint inhibitors in head and neck squamous cell carcinomas: an approach of complementary advantages
Squamous cell carcinomas are the most common head and neck malignancies. Significant progress has been made in standard therapeutic methods combining surgery, radiation, and chemotherapy. Nevertheless, the 5-y...
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Article
Using network pharmacological analysis and molecular docking to investigate the mechanism of action of quercetin’s suppression of oral cancer
This investigation seeks to explore the mechanism of quercetin in oral cancer by incorporating network pharmacology analysis and molecular docking.
