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Article
Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks
Mortalin (encoded by HSPA9) is a mitochondrial chaperone often overexpressed in cancer through as-yet-unknown mechanisms. By searching different RNA-sequencing datasets, we found that ESRRA is a transcription fac...
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Article
Open AccessSafety evaluation method of bottom coal thickness in thick coal seam roadway
In recent years, the number of roadway floor rock burst accidents is increasing, which seriously restricts the safe production of the mine. Therefore, safety evaluation method of bottom coal thickness in thick...
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Article
Open AccessAssociation between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study
We investigated the association between exercise habits before or after thyroidectomy and incident type 2 diabetes mellitus (T2DM) in patients with thyroid cancer.
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Article
Hierarchical Self-assembly of Atomically Precise Au Nanoclusters with Molecular Rotor-based Ligands
The hierarchical assemblies of precise nanoparticles (NPs) have created materials with emergent properties and functionalities. However, the complex assemblies remain unclear at a precise scale. Here, we show ...
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Article
Open AccessA multiscale analysis of the relationship between urbanization and CO2 emissions using geo-weighted regression model
It is of great practical significance to explore the relationship between urbanization and CO2 emissions for the low-carbon development of cities. However, the multiscale assessment of spatial relationship betwee...
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Article
Open AccessPlasma exosomes from patients with active thyroid-associated orbitopathy induce inflammation and fibrosis in orbital fibroblasts
The pathogenesis of thyroid-associated orbitopathy (TAO) remains incompletely understand. The interaction between immunocytes and orbital fibroblasts (OFs) play a critical role in orbital inflammatory and fibr...
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Article
Building on prior lightweight CNN model combined with LSTM-AM framework to guide fault detection in fixed-wing UAVs
Fixed-wing UAVs (FW-UAVs) are empowered to handle diverse civilian and military missions, but sensor failure scenarios are constantly rising. Rapid advancement in deep learning methods currently proposes state...
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Article
Privacy-Preserving Frank-Wolfe on Shuffle Model
In this paper, we design the differentially private variants of the classical Frank-Wolfe algorithm with shuffle model in the optimization of machine learning. Under weak assumptions and the generalized linear...
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Article
Continuous and size-control synthesis of lipopolyplex nanoparticles enabled by controlled micromixing performance for mRNA delivery
Accurate control of core–shell lipopolyplex nanoparticles (LPP NPs) size is crucial for finely adjusting their biomedical performance. However, the synthesis of LPP NPs encounters challenges as two mixing-sens...
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Article
Identifying top-k influential nodes in social networks: a discrete hybrid optimizer by integrating butterfly optimization algorithm with differential evolution
The most challenge of influence maximization (IM) is to locate a finite set of influencers while maximizing the influence dissemination in a social network. Due to the increasingly widespread and complex appli...
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Article
Comparative evaluation of fermented ginseng on alleviating antibiotic-associated diarrhea in mice
Antibiotic associated diarrhea (AAD) was a common side effect of antibiotics, and fermented ginseng exhibited potential in treating AAD. In this study, the effects of fermented red, white, and black ginseng on...
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Article
An extraction and novelty evaluation framework for technology knowledge elements of patents
Technology knowledge elements play an important role in technology innovation. However, there is still challenges about their extraction and evaluation. Traditional methods exhibit limitations in precisely lin...
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Article
Open AccessWidely-targeted metabolomics and transcriptomics identify metabolites associated with flowering regulation of Choy Sum
Choy Sum, a stalk vegetable highly valued in East and Southeast Asia, is characterized by its rich flavor and nutritional profile. Metabolite accumulation is a key factor in Choy Sum stalk development; however...
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Article
Hosts of Sn in reduced deep-seated W skarn systems: A case study on the world-class scheelite skarn deposit, Zhuxi, South China
Tin (Sn) and tungsten (W) behave incompatibly in reduced magmatic systems and may become enriched in late highly-evolved melts. Nonetheless, Sn and W rarely concentrate in the same deposit. In deposits formed ...
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Article
Quantitative Analysis of Perceived Saltiness through Combination of Sensory Evaluation and Electronic Tongue and its Method Validation
A quantitative analysis of perceived saltiness was established by combining sensory perceived NaCl concentration with electronic tongue salty response. Saltiness index (SI) was defined as the ratio of perceive...
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Article
The association between renal pelvis urine density and the risk of severe infectious complications in patient with symptom-free hydronephrosis after shock wave lithotripsy: a multi-center prospective study
Finding reliable and easy-to-obtain predictors of severe infectious complications after shock wave lithotripsy (SWL) is a major clinical need, particular in symptom-free hydronephrosis. Therefore, we aim to pr...
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Article
Open Access17 variants interaction of Wnt/β-catenin pathway associated with development of osteonecrosis of femoral head in Chinese Han population
The genes of Wnt/β-catenin pathway may have potential roles in fat accumulation of Non-traumatic osteonecrosis of the femoral head (ONFH), but the effects of their variants in the pathway on ONFH development h...
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Article
Open AccessA graph convolutional network with dynamic weight fusion of multi-scale local features for diabetic retinopathy grading
Diabetic retinopathy (DR) is a serious ocular complication that can pose a serious risk to a patient’s vision and overall health. Currently, the automatic grading of DR is mainly using deep learning techniques...
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Article
Open AccessEarly warning signals for stock market crashes: empirical and analytical insights utilizing nonlinear methods
This study introduces a comprehensive framework grounded in recurrence analysis, a tool of nonlinear dynamics, to detect potential early warning signals (EWS) for imminent phase transitions in financial system...
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Article
Long-term outcomes of endoscopic or surgical resection in T1 colorectal cancer patients: a retrospective cohort study
The personalized treatments of T1 colorectal cancer (CRC) remains controversial. We compared the long-term outcomes of T1 CRC patients after endoscopic resection (ER) and surgery, and evaluated the risk factor...
