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Open AccessAssociations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study
Prior studies have reported conflicting results regarding the association of prenatal maternal depression with offspring cortisol levels. We examined associations of high levels of prenatal depressive symptoms...
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Open AccessAnalysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molec...
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Open AccessAuthor Correction: Genetic effects on the timing of parturition and links to fetal birth weight
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Open AccessDNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort
Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment. The aim of this study was to e...
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Open AccessGenetic effects on the timing of parturition and links to fetal birth weight
The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,55...
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Open AccessAdolescent overeating and binge eating behavior in relation to subsequent cardiometabolic risk outcomes: a prospective cohort study
Binge eating disorder is bidirectionally associated with obesity and with metabolic syndrome. It is less clear whether overeating and binge eating, or overeating with loss of control, also predicts metabolic r...
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Open AccessAssociation of total lifetime breastfeeding duration with midlife handgrip strength: findings from Project Viva
Lactation has long term effects on maternal health, but the relationship between lactation and long-term handgrip strength, a marker of musculoskeletal function and healthy aging, has not been explored.
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Open AccessHistory of infertility and pregnancy outcomes in Project Viva: a prospective study
Infertility has been associated with the risk of adverse pregnancy outcomes. It is not clear whether infertility and underlying causes of infertility or the use of medically assisted reproduction (MAR) therapi...
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Open AccessLongitudinal associations of DNA methylation and sleep in children: a meta-analysis
Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have bee...
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Open AccessMeta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills
Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general...
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Open AccessCesarean delivery and metabolic health and inflammation biomarkers during mid-childhood and early adolescence
We assessed differences in plasma levels of metabolic health and inflammation biomarkers during mid-childhood and early adolescence between children born by cesarean section vs. vaginal delivery.
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Open AccessPrenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals
Prenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal ex...
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Open AccessDNA methylation architecture of the ACE2 gene in nasal cells of children
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to the global coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2 enters cells via angiotensin-Converting Enzyme 2 (ACE2) receptors, hi...
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Open AccessEpigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated...
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Open AccessWomen’s perceived social support: associations with postpartum weight retention, health behaviors and depressive symptoms
Social support may promote healthful behaviors that prevent excess weight at critical periods in women’s life. Our objective was to investigate associations of social support at 6 months postpartum with women’...
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Open AccessEvaluation of the impact of calorie labeling on McDonald’s restaurant menus: a natural experiment
The long-term effect of calorie labeling on fast-food purchases is unclear. McDonald’s voluntarily labeled its menus with calories in 2012, providing an opportunity to evaluate this initiative on purchases.
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Open AccessThe nasal methylome as a biomarker of asthma and airway inflammation in children
The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylat...
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Correction: Maternal obesity and offspring cognition: the role of inflammation
Following publication of this article, the authors noted that the name of the last author was incorrectly displayed as ‘Sen Sarbattama’. This authors name has now been corrected to ‘Sarbattama Sen’. This has b...
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Open AccessPrenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood
Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with c...
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Open AccessDietary behaviors throughout childhood are associated with adiposity and estimated insulin resistance in early adolescence: a longitudinal study
Despite the growing prevalence of excess weight and prediabetes in children, the contributing role of dietary behaviors throughout childhood remains poorly understood. We examined longitudinal associations of ...