10 Result(s)
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Open AccessAnalysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molec...
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Article
Open AccessAuthor Correction: Genetic effects on the timing of parturition and links to fetal birth weight
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Open AccessDNA methylation age at birth and childhood: performance of epigenetic clocks and characteristics associated with epigenetic age acceleration in the Project Viva cohort
Epigenetic age acceleration (EAA) and epigenetic gestational age acceleration (EGAA) are biomarkers of physiological development and may be affected by the perinatal environment. The aim of this study was to e...
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Open AccessGenetic effects on the timing of parturition and links to fetal birth weight
The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,55...
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Open AccessLongitudinal associations of DNA methylation and sleep in children: a meta-analysis
Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have bee...
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Open AccessPrenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals
Prenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA methylation (DNAm) may be involved in pathways linking prenatal metal ex...
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Open AccessPrenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood
Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, and depression with c...
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Open AccessEpigenome-wide association study of total serum immunoglobulin E in children: a life course approach
IgE-mediated sensitization may be epigenetically programmed in utero, but early childhood environment may further alter complex traits and disease phenotypes through epigenetic plasticity. However, the epigeno...
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Open AccessCord blood DNA methylation and adiposity measures in early and mid-childhood
Excess adiposity in childhood is associated with numerous adverse health outcomes. As this condition is difficult to treat once present, identification of risk early in life can help inform and implement strat...
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Open AccessBirth weight-for-gestational age is associated with DNA methylation at birth and in childhood
Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic mec...
