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Article
GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver
Dysregulated metabolism, cell death, and inflammation contribute to the development of metabolic dysfunction-associated steatohepatitis (MASH). Pyroptosis, a recently identified form of programmed cell death, ...
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Article
Open AccessCombining single-cell and bulk RNA sequencing, NK cell marker genes reveal a prognostic and immune status in pancreatic ductal adenocarcinoma
The NK cell is an important component of the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC), also plays a significant role in PDAC development. This study aimed to explore the relationship b...
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Article
Open AccessEpistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin
The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin ...
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Article
Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
Managing renal fibrosis is challenging owing to the complex cell signaling redundancy in diseased kidneys. Renal fibrosis involves an immune response dominated by macrophages, which activates myofibroblasts in...
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Article
Research on the determination method of biomass dielectric properties based on mixing rules
Knowledge of the dielectric properties of a given biomass resource is essential for develo** microwave-assisted thermochemical conversion of biomass. In this study, a promising strategy was developed to accu...
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Article
Open AccessDEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...
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Article
Open AccessA pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...
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Article
Open AccessMeasurement of Born cross section of \( {e}^{+}{e}^{-}\to {\Sigma}^{+}{\overline{\Sigma}}^{-} \) at center-of-mass energies between 3.510 and 4.951 GeV
Using 24.1 fb−1 of e+e− collision data collected with the BESIII detector at the BEPCII collider, the Born cross sections and effective form factors of the ...
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Article
Graphene nanoribbons grown in hBN stacks for high-performance electronics
Van der Waals encapsulation of two-dimensional materials in hexagonal boron nitride (hBN) stacks is a promising way to create ultrahigh-performance electronic devices1–4. However, contemporary approaches for achi...
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Article
FAP is a prognostic marker, but not a viable therapeutic target for clinical translation in HNSCC
PD-1 targeted immunotherapy has imparted a survival benefit to advanced head and neck squamous cell carcinoma (HNSCC), but less than 20% patients produce a durable response to this therapy. Here we aimed to in...
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Article
Strain-promoted S-arylation and alkenylation of sulfinamides using arynes and cyclic alkynes
The conversion of commercially available chiral sulfinamides into pharmaceutically useful chiral sulfoximines via direct SIV-functionalization is synthetically attractive but challenging due to the competitive re...
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Article
Transcriptome analysis of the bloom-forming dinoflagellate Prorocentrum donghaiense exposed to Ginkgo biloba leaf extract, with an emphasis on photosynthesis
Ginkgo biloba leaf extract (GBE) can effectively treat bloom-forming freshwater algae. However, there is limited information about the underlying suppression mechanism of the marine bloom-forming Prorocentrum do...
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Article
Open AccessPro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
Senescence of vascular smooth muscle cells (VSMCs) contributes to aging-related cardiovascular diseases by promoting arterial remodelling and stiffness. Ferroptosis is a novel type of regulated cell death asso...
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Article
Open AccessMeasurement of \( {e}^{+}{e}^{-}\to p{K}^{-}\overline{\Lambda}+c.c. \) cross sections between 4.009 GeV and 4.951 GeV
Using e+e− collision datasets corresponding to a total integrated luminosity of 21.7 fb−1 collected with the BESIII detector at the BEPCII collider at center-of-mass energies ranging from 4.009 GeV to 4.951 GeV, ...
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Article
Open AccessMeasurement of the cross section of \( {e}^{+}{e}^{-}\to {\**}^{-}{\overline{\**}}^{+} \) at center-of-mass energies between 3.510 and 4.843 GeV
Using e+e− collision data corresponding to a total integrated luminosity of 12.9 fb−1 collected with the BESIII detector at the BEPCII collider, the exclusive Born cross sections and the effective form factors of...
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Article
Open AccessSTCF conceptual design report (Volume 1): Physics & detector
The super τ-charm facility (STCF) is an electron–positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak lumino...
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Article
Open AccessSafety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study
AD16 is a Class 1.1 new drug candidate for Alzheimer’s disease (AD), which has demonstrated potential benefits in AD by reducing neuroinflammation in preclinical studies. Herein, the pharmacokinetics (PK), saf...
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Article
Open AccessCore–Shell Microfiber Encapsulation Enables Glycerol-Free Cryopreservation of RBCs with High Hematocrit
We developed a novel method for high-efficiency, nontoxic, glycerol-free, scalable cryopreservation of human red blood cells with a high hematocrit (> 40%)...
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Article
Open AccessSAPT: a synchrotron-based proton therapy facility in Shanghai
Because of its excellent dose distribution, proton therapy is becoming increasingly popular in the medical application of cancer treatment. A synchrotron-based proton therapy facility was designed and construc...
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Article
A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals
Fully implantable wireless systems for the recording and modulation of neural circuits that do not require physical tethers or batteries allow for studies that demand the use of unconstrained and freely behavi...
