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  1. Article

    Open Access

    miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway

    Kinesin family member 26B (KIF26B) is unveiled acted as important role in many solid tumors, however, the function of KIF26B in hepatocellular carcinoma (HCC) is unclear.

    Hua Li, Shen Shen, **aolong Chen, Zhigang Ren, Zhiqin Li… in Cancer Cell International (2019)

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  2. No Access

    Article

    Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

    Leber congenital amaurosis type 10 is a severe retinal dystrophy caused by mutations in the CEP290 gene1,2. We developed EDIT-101, a candidate genome-editing therapeutic, to remove the aberrant splice donor creat...

    Morgan L. Maeder, Michael Stefanidakis, Christopher J. Wilson… in Nature Medicine (2019)

  3. No Access

    Article

    From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma

    Although the investigation into biomarkers specific for pulmonary metastasis within osteosarcoma (OS) has recently expanded, their usage within the clinic remains sparse. The current screening protocol after a...

    Dylan C. Dean, Shen Shen, Francis J. Hornicek… in Cancer and Metastasis Reviews (2018)