19 Result(s)
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Open AccessEvolution of ferromagnetic cluster in perovskite La0.88Sr0.12MnO3 nanocrystalline detected by EPR spectrum
Electron paramagnetic resonance (EPR) studies were performed on La0.88Sr0.12MnO3 (LSMO) nanocrystalline together with the measurement of its magnetization. Various spectrum parameters including line width, effect...
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Open AccessHighly stable and antifungal properties on the oilseed rape of Cu3(MoO4)2(OH)2 nanoflakes prepared by simple aqueous precipitation
In the last few decades, nanoparticles have been a prominent topic in various fields, particularly in agriculture, due to their unique physicochemical properties. Herein, molybdenum copper lindgrenite Cu3(MoO4)2(...
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Open AccessEffects of climate factors and Demodex infestation on meibomian gland dysfunction-associated dry eye diseases
We examined the effects of climatic factors and Demodex infestations on meibomian gland dysfunction (MGD)-associated dry eye disease (DED) in a cross-sectional study. This study included 123 patients from Tian...
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Open AccessInterfacial friction enabling ≤ 20 μm thin free-standing lithium strips for lithium metal batteries
A practical high-specific-energy Li metal battery requires thin (≤20 μm) and free-standing Li metal anodes, but the low melting point and strong diffusion creep of lithium metal impede their scalable processin...
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Article
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across all cancer types1. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform has been shown to play an import...
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Open AccessSTING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer
PARP inhibitors (PARPi) have drastically changed the treatment landscape of advanced ovarian tumors with BRCA mutations. However, the impact of this class of inhibitors in patients with advanced BRCA-mutant breas...
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Open Accessp16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases
Approximately 50% of patients with metastatic HER2-positive (HER2+) breast cancer develop brain metastases (BCBMs). We report that the tumor suppressor p16INK4A is deficient in the majority of HER2+ BCBMs. p16INK...
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Open AccessA combination of CMC and α-MSH inhibited ROS activated NLRP3 inflammasome in hyperosmolarity stressed HCECs and scopolamine-induced dry eye rats
An important mechanism involved in dry eye (DE) is the association between tear hyperosmolarity and inflammation severity. Inflammation in DE might be mediated by the NLRP3 inflammasome, which activated by exp...
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Article
Open AccessThe role of the PIK3CA gene in the development and aging of the brain
The CLOVES syndrome is an overgrowth disease arising from mosaic activating somatic mutations in the PIK3CA gene. These mutations occur during fetal development producing malformation and overgrowth of a variety ...
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Open AccessImproving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method
Breast cancer brain metastasis (BCBM) remains a major clinical problem. Approximately 10–16% of patients with breast cancer develop brain metastases (BCBM). However, no systemic therapy has gained regulatory a...
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Open AccessPower and chirp effects on the frequency stability of resonant dispersive waves generated in photonic crystal fibres
Optimization of laser output parameters vs. f-to-2f beating signals can be mutually contradicting, when an octave-spanning supercontinuum is employed for f-to-2f measurements. We show that resonant dispersive ...
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Article
CDK4/6 inhibition triggers anti-tumour immunity
Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.
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Article
Open AccessA soluble starch synthase I gene, IbSSI, alters the content, composition, granule size and structure of starch in transgenic sweet potato
Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of Ib...
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Open AccessTranscript profile analysis reveals important roles of jasmonic acid signalling pathway in the response of sweet potato to salt stress
Sweet potato is an important food and bio-energy crop, and investigating the mechanisms underlying salt tolerance will provide information for salt-tolerant breeding of this crop. Here, the root transcriptomes...
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Open AccessAcoustic micro-tap** for non-contact 4D imaging of tissue elasticity
Elastography plays a key role in characterizing soft media such as biological tissue. Although this technology has found widespread use in both clinical diagnostics and basic science research, nearly all metho...
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Open AccessTemporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control
Temporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and defi...
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Open Accessα-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathways
Dry eye is a highly prevalent, chronic and multifactorial disease that compromises quality of life and generates socioeconomic burdens. The pathogenic factors of dry eye disease (DED) include tear secretion ab...
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Open AccessTraining of Working Memory Impacts Neural Processing of Vocal Pitch Regulation
Working memory training can improve the performance of tasks that were not trained. Whether auditory-motor integration for voice control can benefit from working memory training, however, remains unclear. The ...
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Open AccessAttention Modulates Cortical Processing of Pitch Feedback Errors in Voice Control
Considerable evidence has shown that unexpected alterations in auditory feedback elicit fast compensatory adjustments in vocal production. Although generally thought to be involuntary in nature, whether these ...
