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  1. Article

    Open Access

    Functional investigation of SLC1A2 variants associated with epilepsy

    Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing excitotoxicity via clear...

    Qi Qu, Wenlong Zhang, Ji Wang, Dongmei Mai, Siqiang Ren… in Cell Death & Disease (2022)

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  2. Article

    Open Access

    Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease

    Rapamycin protects mice against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced loss of dopaminergic neurons, which is an established model for Parkinson’s disease. We demonstrated that rapamycin p...

    Yunlong Zhang, **aoliang He, **aojuan Wu, Ming Lei, Zhiyun Wei… in Cell Death & Disease (2017)

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  3. Article

    Open Access

    Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model

    Glutamate transporters play a key role in glutamate clearance and protect the central nervous system from glutamate excitotoxicity. Dysfunctional glutamate transporters contribute to the pathogenesis of Parkin...

    Yunlong Zhang, **aoliang He, **ngjun Meng, … in Cell Death & Disease (2017)

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  4. No Access

    Article

    Suppression of interleukin 17 contributes to the immunomodulatory effects of adipose-derived stem cells in a murine model of systemic lupus erythematosus

    Due to roles in immunoregulation and low immunogenicity, mesenchymal stem cells have been suggested to be potent regulators of the immune response and may represent promising treatments for autoimmune disease....

    **aoliang He, Yunlong Zhang, Ai Zhu, Kang Zeng, ** Zhang… in Immunologic Research (2016)