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Article

The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy

MK-8776 is a recently described inhibitor that is highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies s...

Zhi-rui Zhou, Zhao-zhi Yang, Shao-jia Wang, Li Zhang… in Acta Pharmacologica Sinica (2017)