31 Result(s)
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Open AccessConstruction of warfarin population pharmacokinetics and pharmacodynamics model in Han population based on Bayesian method
The purpose of this paper is to study the genetic polymorphisms of related gene loci (CYP2C9*3, VKORC1-1639G > A) based on demographic and clinical factors, and use the maximum a posterior Bayesian method to c...
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Open AccessThe PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation
CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of p...
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Open AccessPrecise prediction of phase-separation key residues by machine learning
Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the key residues, which impact phase separation the most...
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Open AccessExperimental confirmation of driving pressure boosting and smoothing for hybrid-drive inertial fusion at the 100-kJ laser facility
In laser-driven inertial confinement fusion, driving pressure boosting and smoothing are major challenges. A proposed hybrid-drive (HD) scheme can offer such ideal HD pressure performing stable implosion and n...
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Open AccessMagnetic Janus origami robot for cross-scale droplet omni-manipulation
The versatile manipulation of cross-scale droplets is essential in many fields. Magnetic excitation is widely used for droplet manipulation due to its distinguishing merits. However, facile magnetic actuation ...
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Open AccessAuthor Correction: High-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile
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Open AccessHigh-performance Marangoni hydrogel rotors with asymmetric porosity and drag reduction profile
Miniaturized rotors based on Marangoni effect have attracted great attentions due to their promising applications in propulsion and power generation. Despite intensive studies, the development of Marangoni rot...
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Open AccessReward and aversion processing by input-defined parallel nucleus accumbens circuits in mice
The nucleus accumbens (NAc) is critical in mediating reward seeking and is also involved in negative emotion processing, but the cellular and circuitry mechanisms underlying such opposing behaviors remain elus...
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Open AccessStable solar water splitting with wettable organic-layer-protected silicon photocathodes
Protective layers are essential for Si-based photocathodes to achieve long-term stability. The conventionally used inorganic protective layers, such as TiO2, need to be free of pinholes to isolate Si from corrosi...
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Open AccessComprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity
The insights into how genome topology couples with epigenetic states to govern the function and identity of the corneal epithelium are poorly understood. Here, we generate a high-resolution Hi-C interaction ma...
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Open AccessQuantitative observation of monochromatic X-rays emitted from implosion hotspot in high spatial resolution in inertial confinement fusion
In inertial confinement fusion, quantitative and high-spatial resolution ( \(< 10\,\upmu \) ...
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Open AccessAMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections
Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial quality control mitophagy ...
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CRL4AMBRA1 is a master regulator of D-type cyclins
D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer1, but the mechanisms that regulate their turnover are still being...
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Open AccessGeographical distribution of the dispersal ability of alien plant species in China and its socio-climatic control factors
Dispersal ability is important for the introduction, establishment, and spread of alien plant species. Therefore, determination of the geographical distribution of the dispersal ability of such species, and th...
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Open AccessHigh-purity foam-like micron-sized gold cage material with tunable plasmon properties
Herein, by growing mono dispersed gold nanoparticles (MNPAu) on the surface of polystyrene (PS)/nanogold (Au) core–shell composites (PS@Au), we successfully synthesized a micron-sized gold cage (2.6–10.7 μm), ...
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Open AccessRole of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes
Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective int...
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Open AccessRapidly and exactly determining postharvest dry soybean seed quality based on machine vision technology
The development of machine vision-based technologies to replace human labor for rapid and exact detection of agricultural product quality has received extensive attention. In this study, we describe a low-rank...
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Open AccessA high temporal resolution numerical algorithm for shock wave velocity diagnosis
We propose a high temporal resolution numerical algorithm for shock wave velocity diagnosis. By analysing variations in the optical path and phasor of a light field, we determine a high temporal resolution sho...
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Open AccessFirst exploration of radiation temperatures of the laser spot, re-emitting wall and entire hohlraum drive source
This study explores the radiation field temperatures introduced by the laser spot, the re-emitting wall in a hohlraum and the entire hohlraum drive source. This investigation, which is the first of its kind, i...
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Open AccessExploring the Holiday Effect on Air Temperatures
Anthropogenic emissions are generally lower during holidays than they are on workdays, this pattern is expected to result in temperature variations. Variations in the daily maximum (Tmax), mean (Tmean) and minimu...
