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    Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

    Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so ...

    Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee… in Molecular Neurodegeneration (2024)

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