12 Result(s)
within
Seon Young Kim
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCILP2 is a potential biomarker for the prediction and therapeutic target of peritoneal metastases in colorectal cancer
Peritoneal metastases (PM) in colorectal cancer (CRC) is associated with a dismal prognosis. Identifying and exploiting new biomarkers, signatures, and molecular targets for personalised interventions in the t...
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Article
Open AccessTranscriptomic characteristics according to tumor size and SUVmax in papillary thyroid cancer patients
The SUVmax is a measure of FDG uptake and is related with tumor aggressiveness in thyroid cancer, however, its association with molecular pathways is unclear. Here, we investigated the relationship between SUVmax
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Article
Open AccessUnraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses
The role of the serine/glycine metabolic pathway (SGP) has recently been demonstrated in tumors; however, the pathological relevance of the SGP in thyroid cancer remains unexplored. Here, we perform metabolomi...
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Article
Open AccessA threonyl-tRNA synthetase-mediated translation initiation machinery
A fundamental question in biology is how vertebrates evolved and differ from invertebrates, and little is known about differences in the regulation of translation in the two systems. Herein, we identify a thre...
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Article
Open AccessAuthor Correction: nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
In the original version of the Supplementary Information file associated with this Article, Supplementary Fig. 18 panel b was inadvertently replaced with a duplicate of panel a. The error has now been fixed an...
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Article
Open AccessClinical and genomic landscape of gastric cancer with a mesenchymal phenotype
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP...
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Article
Open Accessnc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expr...
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Open AccessA late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis
Homeostasis of neutrophils—the blood cells that respond first to infection and tissue injury—is critical for the regulation of immune responses and regulated through granulopoiesis, a multi-stage process by wh...
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Article
Open AccessA proteogenomic approach for protein-level evidence of genomic variants in cancer cells
Variations in protein coding sequence may sometimes play important roles in cancer development. However, since variants may not express into proteins due to various cellular quality control systems, it is impo...
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Article
Open AccessGSF2 deletion increases lactic acid production by alleviating glucose repression in Saccharomyces cerevisiae
Improving lactic acid (LA) tolerance is important for cost-effective microbial production of LA under acidic fermentation conditions. Previously, we generated LA-tolerant D-LA-producing S. cerevisiae strain JHY53...
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Article
Open AccessLATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells, but its role in cell fate determination and differentiation during liver development remains unclear. Here we repor...
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Article
Open AccessA basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness
The switch between stem/progenitor cell expansion and differentiation is critical for organ homeostasis. The mammalian Hippo pathway effector and oncoprotein YAP expands undifferentiated stem/progenitor cells ...
