44 Result(s)
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Chapter
Circadian Organization of the Immune Response
Organisms populating the Earth are under the steady influence of daily and seasonal changes resulting from the planet's rotation and orbit around the sun. This periodic pattern is most prominently manifested b...
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Circadian control by serotonin and melatonin receptors: Clinical relevance
This chapter reviews the role of the different serotonin receptors located in the circadian apparatus and their possible clinical implications for the activity of antidepressants. The central oscillator locate...
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Article
Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms, sleep homeo...
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Article
Open AccessObjective assessment of drowsiness and reaction time during intermittent Ramadan fasting in young men: a case-crossover study
Ramadan fasting and its attendant lifestyle changes induce changes in the circadian rhythm and in associated physiological and metabolic functions. Previous studies that have assessed psychomotor performance d...
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Chapter
Sodium Oxybate (Xyrem®): A New and Effective Treatment for Narcolepsy with Cataplexy
Sodium oxybate (SXB; Xyrem®) is the sodium salt of gamma hydroxybutyric acid (GHB). SXB has been approved in the United States for the treatment of cataplexy and excessive daytime sleepiness (EDS) in patients wit...
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Article
The SAVE Trial: Has the Importance of CPAP for Preventing Cardiovascular Events been Discounted?
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Article
Inaugural Issue of Sleep and Vigilance: Prospects and Promises
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Chapter
The Effects of Melanin-Concentrating Hormone on Neurotransmitter Systems Involved in the Generation and Maintenance of Wakefulness
Within the central nervous system (CNS), melanin-concentrating hormone (MCH) participates in a number of functions including sleep-wake behavior. In this respect, MCHergic neurons project widely throughout the...
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The Involvement of 5-HT2A Receptor in the Regulation of Sleep and Wakefulness, and the Potential Therapeutic Use of Selective 5-HT2A Receptor Antagonists and Inverse Agonists for the Treatment of an Insomnia Disorder
Several agents have been shown to improve sleep induction and/or maintenance in patients with primary or comorbid insomnia. These include benzodiazepine and non-benzodiazepine receptor allosteric modulators, m...
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Article
Chronobiological theories of mood disorder
Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellat...
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Article
Sleep, Oh Sleep, Where Art Thou?
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Article
Why We Sleep: The New Science of Sleep and Dreams by Matthew Walker, Ph.D.
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Article
Selective Serotonin 5-HT2A Receptor Antagonists and Inverse Agonists Specifically Promote Slow Wave Sleep (Stage N3) in Man
Several drug classes are widely prescribed when difficulties with sleep induction or sleep maintenance occur, as is the case in patients with an insomnia disorder. These include the benzodiazepine and non-benz...
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Article
Addictive Substances and Sleep: More Research is Needed
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Article
Sleep and circadian rhythms in health and disease: a complex interplay
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Article
Siesta: Still an Enigma
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Article
“Sleep Well, Sleep on Time” and Insufficient Sleep: A Need for More Research and Public Health Policies
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Article
Elderly as a High-risk Group during COVID-19 Pandemic: Effect of Circadian Misalignment, Sleep Dysregulation and Melatonin Administration
The association of age with a higher vulnerability to COVID-19 infection is a subject of major importance. Several factors, including higher stress due to social isolation, diminished melatonin levels with age...
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Article
An Egyptian Study of Sleep Disorders and Its Correlates in End-Stage Renal Disease Patients Receiving Hemodialysis
Various sleep disorders are reported to be frequent in end-stage renal disease (ESRD) patients on hemodialysis. This study aimed to assess the prevalence of sleep disorders and their correlates among hemodialy...
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Article
India’s Manned Spaceflight: Incisive Perspectives on the Vigilance of the Crew During the Mission
During staffed space flight missions, the astronauts’ circadian timing system and sleep are altered not only due to the microgravity environment but also due to the intense environmental stimulus. Loss of slee...
