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    Article

    Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

    The spliceosome excises introns from pre-messenger RNAs using an RNA-based active site that is cradled by a dynamic protein scaffold. A recent revolution in cryo-electron microscopy (cryo-EM) has led to near-a...

    Sebastian M Fica, Kiyoshi Nagai in Nature Structural & Molecular Biology (2017)

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    Article

    Evidence for a group II intron–like catalytic triplex in the spliceosome

    It has long been thought that the catalytic RNAs of self-splicing group II introns and the spliceosome function by similar mechanisms. Now, a combination of genetic, cross-linking, and biochemical analyses of ...

    Sebastian M Fica, Melissa A Mefford… in Nature Structural & Molecular Biology (2014)