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  1. Article

    Open Access

    Splicing is an alternate oncogenic pathway activation mechanism in glioma

    High-grade diffuse glioma (HGG) is the leading cause of brain tumour death. While the genetic drivers of HGG have been well described, targeting these has thus far had little impact on survival suggesting othe...

    Robert Siddaway, Scott Milos, Arun Kumaran Anguraj Vadivel… in Nature Communications (2022)

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  2. Article

    Open Access

    Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

    Histone H3 lysine 27 (H3K27M) mutations represent the canonical oncohistone, occurring frequently in midline gliomas but also identified in haematopoietic malignancies and carcinomas. H3K27M functions, at leas...

    Sanja Pajovic, Robert Siddaway, Taylor Bridge, Javal Sheth… in Nature Communications (2020)

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