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Article
Stabilizing Peptide Fusion for Solving the Stability and Solubility Problems of Therapeutic Proteins
Protein aggregation is a major stability problem of therapeutic proteins. We investigated whether a novel stabilizing peptide [acidic tail of synuclein (ATS) peptide] could be generally used to make a more sta...
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Article
Synthesis and anti-inflammatory and analgesic activities of pyridyloxy- and phenoxyalkanoic acid derivatives
Synthesis of pyridyloxy-, pyridyloxyphenoxy- and phenoxylphenoxyalkanate derivatives and their anti-inflammatory and analgesic activities were investigated. Analysis of structure-activity relationships showed ...
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Article
Synthesis and activity of a potent α-glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer
The synthesis ofcis- and trans-1,6-dihydroxypyrrolizidine starting fromtrans-4-hydroxyl-L-proline and their evaluation as glycosidase inhibitors are reported. Thecis-isomer was found to be a potent inhibitor agai...
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Article
Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives
The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives ant...
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Article
A stereoselective route to a cyclopentanoid natural product synthon via intramolecular ester enolate alkyaltion
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Article
Synthetic β-lactam antibiotics VI. Antibacterial activity of some 7β-[-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(pyrrolidinium) methylcephalosporins
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Article
Synthetic β-lactam antibiotics V. Antibacterial activity of some 7β-[2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(quinolinium)thiomethylcephalosporins
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Article
Synthesis and antibacterial activities of triphenyltin cephalosporins
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Article
Reactivity of 7-dithiocarboxy-imidazo[2,1-b]thiazoliumbetaine with aliphatic alkylating agents
We have reported earlier on the reactivity of 7-dithiocarboxy-3-phenyl-5,6-dihydro imidazo[2,1-b]thiazolium-betaine with severalpara-substituted phenacyl bromides. In this work reactions of 7-dithiocarboxy-3-phen...