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Article

Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin

Omics techniques have been increasingly recognized as promising tools for Next Generation Risk Assessment. Targeted metabolomics offer the advantage of providing readily interpretable mechanistic information a...

Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes, Varun Giri… in Archives of Toxicology (2023)