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Article

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. In this study, we characterize 16 novel PDGFRA mutations identi...

Carman K. M. Ip, Patrick K. S. Ng, Kang ** Jeong, S. H. Shao… in Nature Communications (2018)