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  1. No Access

    Article

    Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

    Orexin-1 receptor antagonists have been shown to block the reinforcing effects of drugs of abuse and food. However, whether blockade of orexin-2 receptor has similar effects has not been determined. We have re...

    James R. Shoblock, Natalie Welty, Leah Aluisio, Ian Fraser… in Psychopharmacology (2011)

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    Article

    JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats

    A few recent studies suggest that brain histamine levels and signaling via H3 receptors play an important role in modulation of alcohol stimulation and reward in rodents.

    Ruggero Galici, Amir H. Rezvani, Leah Aluisio, Brian Lord… in Psychopharmacology (2011)

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    Article

    In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

    The lack of potent, selective, brain penetrant Y2 receptor antagonists has hampered in vivo functional studies of this receptor.

    James R. Shoblock, Natalie Welty, Diane Nepomuceno, Brian Lord… in Psychopharmacology (2010)