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Chapter and Conference Paper
Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in Experimental Tumours In Vivo
Extracellular acidosis is a characteristic of solid tumours, resulting from hypoxia-induced glycolytic metabolism as well as from the “Warburg effect” (aerobic glycolysis). The acidic environment has shown to ...
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Chapter and Conference Paper
Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells
Signalling pathways such as ERK1/2, p38 or PI3K are activated in tumour cells by extracellular acidosis, which is a common phenomenon in human tumours. These signalling pathways can modulate the mitochondrial ...
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Chapter and Conference Paper
Role of the mTOR Signalling Pathway During Extracellular Acidosis in Tumour Cells
The metabolic microenvironment of solid tumours is often dominated by extracellular acidosis which results from glycolytic metabolism. Acidosis can modulate gene expression and foster the malignant progression...