14 Result(s)

Article

An unusual, activating insertion/deletion MPL mutant in primary myelofibrosis

J-P Defour, Y Hoade, A-M Reuther, A Callaway, D Ward, F Chen… in Leukemia (2017)

Article

Rethinking JAK2 inhibition: towards novel strategies of more specific and versatile janus kinase inhibition

Janus kinases (JAKs) are required for cytokine receptor signaling. Since the discovery of the highly prevalent JAK2 V617F mutation in myeloproliferative neoplasms (MPNs), JAK2 became a prime target for inhibit...

E Leroy, S N Constantinescu in Leukemia (2017)

Article

Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin

T Balligand, Y Achouri, C Pecquet, I Chachoua, H Nivarthi, C Marty… in Leukemia (2016)

Article

Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms

J-P Defour, I Chachoua, C Pecquet, S N Constantinescu in Leukemia (2016)

Article

Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation

STAT (Signal Transducer and Activator of Transcription) transcription factors are constitutively activated in most hematopoietic cancers. We previously identified a target gene, LPP/miR-28 (LIM domain containing ...

M Girardot, C Pecquet, I Chachoua, J Van Hees, S Guibert, A Ferrant, L Knoops… in Oncogene (2015)

Article

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution

X Cabagnols, J P Defour, V Ugo, J C Ianotto, P Mossuz, J Mondet, F Girodon… in Leukemia (2015)

Article

JAK/STAT signaling in hematological malignancies

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specifi...

W Vainchenker, S N Constantinescu in Oncogene (2013)

Article

Aberrant signal transduction pathways in myeloproliferative neoplasms

The BCR-ABL-negative myeloproliferative neoplasms (MPNs), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF), entered the spotlight in 2005 when the unique somatic acquired JAK...

J Kota, N Caceres, S N Constantinescu in Leukemia (2008)

Article

JAK kinases overexpression promotes in vitro cell transformation

Constitutive activation of the JAK-STAT pathway is frequent in cancer and contributes to oncogenesis. Here, we took advantage of the Ba/F3 cell line, a murine proB cell line dependent on IL-3 for growth, to an...

L Knoops, T Hornakova, Y Royer, S N Constantinescu, J-C Renauld in Oncogene (2008)

Chapter

Transmembrane Signaling by IFN-α

In order to understand the mechanism whereby human interferon alpha (IFN-α) transduces its signal through the plasma membrane, we first must describe the multiple biological effects that are induced by the cyt...

L. M. Pfeffer, S. N. Constantinescu, C. Wang in Biological Response Modifiers — Interferon… (1994)