5 Result(s)

Article

Local anesthetics induce autophagy in young permanent tooth pulp cells

Pulp cells are essential for tooth development, and dentin repair and regeneration. In addition these cells have been identified as an important stem cell source. Local anesthetics are widely used in dental cl...

H Zhuang, D Hu, D Singer, J V Walker, R B Nisr, K Tieu, K Ali… in Cell Death Discovery (2015)

Article

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfo...

M Wang, R Ye, E Barron, P Baumeister, C Mao, S Luo, Y Fu… in Cell Death & Differentiation (2010)

Article

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

Apoptotic cell death is mediated by caspase activation. Autophagy involves the sequestration of cytoplasmic contents into autophagosomes for traffic to lysosomes for degradation. Although autophagy is antiapop...

S Luo, D C Rubinsztein in Cell Death & Differentiation (2010)

Article

Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy

S Luo, D C Rubinsztein in Cell Death & Differentiation (2007)