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13 Result(s)

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  1. Article

    Open Access

    Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma

    Lymph node metastasis (LNM) is a vital prognosis factor in patients with papillary thyroid microcarcinoma (PTMC). The study tried to identify clinicopathological factors for LNM of PTMC.

    Y. Luo, Y. Zhao, K. Chen, J. Shen, J. Shi… in Journal of Endocrinological Investigation (2019)

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  2. No Access

    Article

    MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway

    MTA1 is a metastasis-associated protein, which is essential to epithelial-to-mesenchymal transition (EMT). However, information concerning its up- and downstream regulation is rare. We investigated its upstrea...

    L Deng, J Tang, H Yang, C Cheng, S Lu, R Jiang, B Sun in Oncogene (2017)

  3. No Access

    Article

    PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies

    PR1, an HLA-A2-restricted peptide derived from both proteinase 3 and neutrophil elastase, is recognized on myeloid leukemia cells by cytotoxic T lymphocytes (CTLs) that preferentially kill leukemia and contrib...

    M H Qazilbash, E Wieder, P F Thall, X Wang, R Rios, S Lu, S Kanodia… in Leukemia (2017)

  4. Article

    Open Access

    The role and possible mechanism of lncRNA U90926 in modulating 3T3-L1 preadipocyte differentiation

    Obesity is a risk factor for metabolic diseases, while preadipocyte differentiation or adipogenesis is closely related to obesity occurrence. Long noncoding RNAs (lncRNAs) are a unique class of transcripts in ...

    J Chen, Y Liu, S Lu, L Yin, C Zong, S Cui, D Qin… in International Journal of Obesity (2017)

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  5. Article

    Open Access

    Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter

    Key molecular drivers that underlie transformation of colonic epithelium into colorectal adenocarcinoma (CRC) are well described. However, the mechanisms through which clinically targeted pathways are activate...

    X Qu, T Sandmann, H Frierson Jr, L Fu, E Fuentes, K Walter, K Okrah, C Rumpel… in Oncogene (2016)

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  6. Article

    Open Access

    A role for FOXO1 in BCR–ABL1-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemia

    Chronic myeloid leukemia (CML) patients who relapse on imatinib due to acquired ABL1 kinase domain mutations are successfully treated with second-generation ABL1-tyrosine kinase inhibitors (ABL-TKIs) such as d...

    M Wagle, A M Eiring, M Wongchenko, S Lu, Y Guan, Y Wang, M Lackner, L Amler… in Leukemia (2016)

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  7. Article

    Open Access

    Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer

    Agents targeting the PI3K/mTOR signaling axis have shown promise in early-phase clinical trials and are currently being studied in later stages of clinical development in multiple indications. Experience with ...

    L-Y Huw, C O'Brien, A Pandita, S Mohan, J M Spoerke, S Lu, Y Wang… in Oncogenesis (2013)

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  8. No Access

    Article

    HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma

    The hepatitis B virus (HBV) X protein (HBx) has a key role in the molecular pathogenesis of HBV-related hepatocellular carcinoma (HCC). However, the mechanism of HBx-mediated hepatocarcinogenesis remains to be...

    X Qiu, S Dong, F Qiao, S Lu, Y Song, Y Lao, Y Li, T Zeng, J Hu, L Zhang… in Oncogene (2013)

  9. Article

    Erratum to: Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats

    Y. Liu, L. Liu, S. Lu in Journal of Endocrinological Investigation (2011)

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  10. No Access

    Article

    Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats

    Enzymes that degrade the amyloid β-peptide (Aβ) are important regulators of cerebral Aβ levels. High level of Aβ was found in the brain of diabetic patients and diabetic animals. Aim of the study was to invest...

    Y. Liu, L. Liu, S. Lu, D. Wang… in Journal of Endocrinological Investigation (2011)

  11. No Access

    Article

    Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice

    The poor outcome of cancer gene therapy in clinical trials relates in part to insufficient gene delivery to tumor sites. Mesenchymal stem cells (MSCs) represent a new tool for the delivery of therapeutic agent...

    Y Gao, A Yao, W Zhang, S Lu, Y Yu, L Deng, A Yin, Y **a, B Sun, X Wang in Oncogene (2010)

  12. No Access

    Article

    Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

    OBJECTIVE: Both orexin (ORX)- and melanin-concentrating hormone (MCH) are expressed in different neurons in the lateral hypothalamic area (LH), and are considered to have common effects on stimulating food intake...

    J-L Guan, K Uehara, S Lu, Q-P Wang, H Funahashi… in International Journal of Obesity (2002)

  13. No Access

    Article

    Hypertension is associated with a high risk of cancer

    To investigate the possible relationship between hypertension and cancer, a retrospective analysis was carried out using a database including 1225 cases, of which 552 were hypertensives and 673 normotensives. ...

    L **e, K Wu, N Xu, D Chen, J Chen, S Lu in Journal of Human Hypertension (1999)