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  1. No Access

    Article

    MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway

    MTA1 is a metastasis-associated protein, which is essential to epithelial-to-mesenchymal transition (EMT). However, information concerning its up- and downstream regulation is rare. We investigated its upstrea...

    L Deng, J Tang, H Yang, C Cheng, S Lu, R Jiang, B Sun in Oncogene (2017)

  2. Article

    Open Access

    Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter

    Key molecular drivers that underlie transformation of colonic epithelium into colorectal adenocarcinoma (CRC) are well described. However, the mechanisms through which clinically targeted pathways are activate...

    X Qu, T Sandmann, H Frierson Jr, L Fu, E Fuentes, K Walter, K Okrah, C Rumpel… in Oncogene (2016)

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  3. Article

    Open Access

    Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer

    Agents targeting the PI3K/mTOR signaling axis have shown promise in early-phase clinical trials and are currently being studied in later stages of clinical development in multiple indications. Experience with ...

    L-Y Huw, C O'Brien, A Pandita, S Mohan, J M Spoerke, S Lu, Y Wang… in Oncogenesis (2013)

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  4. No Access

    Article

    HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma

    The hepatitis B virus (HBV) X protein (HBx) has a key role in the molecular pathogenesis of HBV-related hepatocellular carcinoma (HCC). However, the mechanism of HBx-mediated hepatocarcinogenesis remains to be...

    X Qiu, S Dong, F Qiao, S Lu, Y Song, Y Lao, Y Li, T Zeng, J Hu, L Zhang… in Oncogene (2013)

  5. No Access

    Article

    Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice

    The poor outcome of cancer gene therapy in clinical trials relates in part to insufficient gene delivery to tumor sites. Mesenchymal stem cells (MSCs) represent a new tool for the delivery of therapeutic agent...

    Y Gao, A Yao, W Zhang, S Lu, Y Yu, L Deng, A Yin, Y **a, B Sun, X Wang in Oncogene (2010)