35 Result(s)
within
S W Duffy
Biomedicine
Drug Resistance
Molecular Medicine
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Article
Open AccessFirst results from five multidisciplinary diagnostic centre (MDC) projects for non-specific but concerning symptoms, possibly indicative of cancer
Patients with non-specific symptoms often experience longer times to diagnosis and poorer clinical outcomes than those with site-specific symptoms. This paper reports initial results from five multidisciplinar...
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Open AccessLikely effect of adding flexible sigmoidoscopy to the English NHS Bowel Cancer Screening Programme: impact on colorectal cancer cases and deaths
From 2013, once-only flexible sigmoidoscopy (FS) at age 55 is being phased into the England National Health Service Bowel Cancer Screening Programme (NHSBCSP), augmenting biennial guaiac faecal occult blood te...
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Open AccessEvaluation of a service intervention to improve awareness and uptake of bowel cancer screening in ethnically-diverse areas
Uptake of bowel cancer screening is lowest in London, in populations of lower socio-economic status, and in particular ethnic or religious groups.
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Open AccessTranslation of research results to simple estimates of the likely effect of a lung cancer screening programme in the United Kingdom
There is considerable interest in the possibility of provision of lung cancer screening services in many developed countries. There is, however, no consensus on the target population or optimal screening regimen.
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Open AccessReduction in interval cancer rates following the introduction of two-view mammography in the UK breast screening programme
The introduction of two-view mammography at incident (subsequent) screens in the National Health Service Breast Screening Programme (NHSBSP) has led to an increased number of cancers detected at screen. Howeve...
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Open AccessA randomised trial of weekend and evening breast screening appointments
There is a need to research interventions that improve access to and convenience of breast cancer screening services.
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Open AccessExplaining the difference in prognosis between screen-detected and symptomatic breast cancers
We analysed 10-year survival data in 19 411 women aged 50–64 years diagnosed with invasive breast cancer in the West Midlands region of the United Kingdom. The aim was to estimate the survival advantage seen i...
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Open AccessPolygenic susceptibility to prostate and breast cancer: implications for personalised screening
We modelled the efficiency of a personalised approach to screening for prostate and breast cancer based on age and polygenic risk-profile compared with the standard approach based on age alone.
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Open AccessMammographic density and its interaction with other breast cancer risk factors in an Asian population
Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear.
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Open AccessMolecular subty** of DCIS: heterogeneity of breast cancer reflected in pre-invasive disease
Molecular profiling has identified at least four subtypes of invasive breast carcinoma, which exhibit distinct clinical behaviour. There is good evidence now that DCIS represents the non-obligate precursor to ...
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Open AccessComparison of discriminatory power and accuracy of three lung cancer risk models
Three lung cancer (LC) models have recently been constructed to predict an individual's absolute risk of LC within a defined period. Given their potential application in prevention strategies, a comparison of ...
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Open AccessMolecular characteristics of screen-detected vs symptomatic breast cancers and their impact on survival
Several recent studies have shown that screen detection remains an independent prognostic factor after adjusting for disease stage at presentation. This study compares the molecular characteristics of screen-d...
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Open AccessCost of a 5-year lung cancer survivor
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Open AccessOne-stop diagnostic breast clinics: how often are breast cancers missed?
The aim of this study was to estimate the number of patients discharged from a symptomatic breast clinic who subsequently develop breast cancer and to determine how many of these cancers had been ‘missed’ at i...
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Open AccessMean sojourn time, overdiagnosis, and reduction in advanced stage prostate cancer due to screening with PSA: implications of sojourn time on screening
This study aimed to assess the mean sojourn time (MST) of prostate cancer, to estimate the probability of overdiagnosis, and to predict the potential reduction in advanced stage disease due to screening with P...
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Open AccessReply: Estimation of lead-time and overdiagnosis in breast cancer screening
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Open AccessComplexities in the estimation of overdiagnosis in breast cancer screening
There is interest in estimating and attributing temporal changes in incidence of breast cancer in relation to the initiation of screening programmes, in particular to estimation of overdiagnosis of breast canc...
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Open AccessReply: Early onset of breast cancer in black British women: how reliable are the findings?
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Open AccessLung cancer screening: the way forward
To take lung cancer screening into national programmes, we first have to answer the question whether low-dose computed tomography (LDCT) screening and treatment of early lesions will decrease lung cancer morta...
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Open AccessSecond breast cancers in a Tuscan case series: characteristics, prognosis, and predictors of survival
Little is known about long-term outcomes following a second breast cancer diagnosis. We describe the epidemiology, characteristics and prognosis of second breast cancers in an Italian cohort. We identified wom...
