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Open AccessErratum to: Procedures and recommended times in the care process of the patient with pancreatic cancer: PAN-TIME consensus between scientific societies
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Open AccessProcedures and recommended times in the care process of the patient with pancreatic cancer: PAN-TIME consensus between scientific societies
Pancreatic cancer (PC) is a disease with bad prognosis. It is usually diagnosed at advanced stages and its treatment is complex. The aim of this consensus document was to provide recommendations by experts tha...
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Open AccessAfatinib demonstrates remarkable activity against HER2-amplified uterine serous endometrial cancer in vitro and in vivo
Uterine serous carcinomas (USCs) are an aggressive form of uterine cancer that may rely on HER2/neu amplification as a driver of proliferation. The objective of this paper is to assess the sensitivity of USC c...
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KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570
Mutation of KIT receptor tyrosine kinase at residue D816 results in ligand-independent constitutive kinase activity. This mutation occurs in most patients with mastocytosis, a myeloproliferative neoplasm, and ...
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FES kinases are required for oncogenic FLT3 signaling
The closely related non-receptor tyrosine kinases FEline Sarcoma (FES) and FEs Related (FER) are activated by cell surface receptors in hematopoietic cells. Despite the early description of oncogenic viral for...
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Relative roles of bone scintigraphy and positron emission tomography in assessing the treatment response of bone metastases
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99mTc-MDP bone scintigraphy and 18F-FDG positron emission tomography in lung and prostate cancer patients: different affinity between lytic and sclerotic bone metastases
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Interleukin-1 Stimulates Arachidonic Acid 15-Hydroxylation in Human Endothelial Cells
lnterleukin-1 (IL-1 ) induces the expression of immediate-early gene encoding for cyclooxygenase in human endothelial cells (EC) [1], and so increases prostanoid production. However, the effect of IL-1 on the ...