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Article
Open AccessTowards a Large-Scale Assessment of the Relationship Between Biological and Chronological Aging: The Inspire Mouse Cohort
Aging is the major risk factor for the development of chronic diseases. After decades of research focused on extending lifespan, current efforts seek primarily to promote healthy aging. Recent advances suggest...
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Article
KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570
Mutation of KIT receptor tyrosine kinase at residue D816 results in ligand-independent constitutive kinase activity. This mutation occurs in most patients with mastocytosis, a myeloproliferative neoplasm, and ...
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Article
FES kinases are required for oncogenic FLT3 signaling
The closely related non-receptor tyrosine kinases FEline Sarcoma (FES) and FEs Related (FER) are activated by cell surface receptors in hematopoietic cells. Despite the early description of oncogenic viral for...
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Article
Poster abstracts
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Article
In vitro activity of mupirocin against methicillin-resistantStaphylococcus aureus isolated from a hospital in Spain
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Article
Insulin-dependent changes in subcellular distribution of liver insulin receptors in obese Zucker rats
Acute hyperinsulinaemias induced by insulin and stimulants of insulin secretion have been shown to cause a translocation of liver insulin receptors from the cell surface to the intracellular compartment, with ...