8 Result(s)
within
S L Vowler
Biomedicine, general
-
Article
Open AccessAberrant expression of minichromosome maintenance protein-2 and Ki67 in laryngeal squamous epithelial lesions
Histological classification of laryngeal epithelial lesions is highly subjective, and methods of cytological detection are not well developed. Improved determination of aberrant cell cycle entry may allow incr...
-
Article
Open AccessA novel immunohistochemical method for estimating cell cycle phase distribution in ovarian serous neoplasms: implications for the histopathological assessment of paraffin-embedded specimens
We have investigated whether immunohistochemical markers can identify differences in cell cycle phase distribution in ovarian serous neoplasms, including borderline tumours of different grades. Sections of nor...
-
Article
Open AccessThyroid carcinoma after Chernobyl latent period, morphology and aggressiveness
The large numbers of papillary thyroid carcinomas that have occurred in those exposed to high levels of short-lived isotopes in fallout after Chernobyl provide a unique opportunity to correlate latency and tum...
-
Article
Open AccessA minimally invasive immunocytochemical approach to early detection of oral squamous cell carcinoma and dysplasia
Squamous dysplasia of the oral cavity indicates increased risk of progression to squamous cell carcinoma (SCC). An important advance would be the development of a minimally invasive assay for identification of...
-
Article
Open AccessImmunohistochemical estimation of cell cycle phase in laryngeal neoplasia
We previously developed an immunohistochemical method for estimating cell cycle state and phase in tissue samples, including biopsies that are too small for flow cytometry. We have used our technique to examin...
-
Article
Open AccessMalignant germ cell tumours of childhood: new associations of genomic imbalance
Malignant germ cell tumours (MGCTs) of childhood are a rare group of neoplasms that comprise many histological subtypes and arise at numerous different sites. Genomic imbalances have been described in these tu...
-
Article
Open AccessBcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer
Survival in small cell lung cancer (SCLC) is limited by the development of chemoresistance. Factors associated with chemoresistance in vitro have been difficult to validate in vivo. Both Bcl-2 and β1-integrin hav...
-
Article
Open AccessIdentification of pathologically insignificant prostate cancer is not accurate in unscreened men
Identification of men harbouring insignificant prostate cancer (PC) is important in selecting patients for active surveillance. Tools have been developed in PSA-screened populations to identify such men based ...
