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  1. No Access

    Article

    A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels

    Long non-coding RNAs (lncRNAs) can regulate the transcript levels of genes in the same genomic region. These locally acting lncRNAs have been found deregulated in human disease and some have been shown to harb...

    T C Messemaker, M Frank-Bertoncelj, R B Marques, A Adriaans, A M Bakker… in Genes & Immunity (2016)

  2. No Access

    Article

    DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts

    In the search for specific genes regulated by DNA methylation in rheumatoid arthritis (RA), we investigated the expression of CXCL12 in synovial fibroblasts (SFs) and the methylation status of its promoter and...

    E Karouzakis, Y Rengel, A Jüngel, C Kolling, R E Gay, B A Michel… in Genes & Immunity (2011)

  3. No Access

    Chapter and Conference Paper

    Pathology of Rheumatoid Arthritis: Molecular and Inflammatory Aspects

    Rheumatoid arthritis (RA) is a chronic systemic disorder with a progressive destruction of joints. The hallmarks of the disease include: (a) inflammation, (b) abnormal humoral and cellular immune responses, an...

    S. Gay, R. E. Gay in Symposium in Immunology VIII (1999)

  4. No Access

    Article

    Long-term treatment of the MRL/lpr mouse with methotrexate and 10-deazaaminopterin

    Female MRL/lpr mice were treated with I.P. doses of methotrexate (MTX) and 10-deazaaminopterin (DAAM) in the range of 1 to 100 mg/kg body weight/week, in two equally divided doses. Treatment began at 7 weeks o...

    J. E. Baggott, S. L. Morgan, L. E. Freeberg, B. B. Hudson… in Agents and Actions (1992)

  5. No Access

    Chapter and Conference Paper

    Oncogenes and Retroviruses in Rheumatoid Arthritis

    Rheumatoid arthritis is a chronic systemic disorder of currently still unknown etiology. Its most serious and debilitating consequences are derived from the destruction of affected joints. An exceedingly large...

    G. Stransky, R. E. Gay, A. Trabandt, W. K. Aicher, S. R. Barnum… in Rheumatoid Arthritis (1992)