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  1. Article

    Open Access

    Cancer of unknown primary (CUP) through the lens of precision oncology: a single institution perspective

    For patients with cancer of unknown primary (CUP), treatment options are limited. Precision oncology, the interplay of comprehensive genomic profiling (CGP) and targeted therapies, aims to offer additional tre...

    L. Weiss, K. Heinrich, D. Zhang, K. Dorman… in Journal of Cancer Research and Clinical On… (2023)

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  2. Article

    Open Access

    Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel

    This pilot study aimed on generating insight on alterations in circulating immune cells during the use of FOLFIRINOX and gemcitabine/nab-paclitaxel in pancreatic ductal adenocarcinoma (PDAC).

    L. Sams, S. Kruger, V. Heinemann, D. Bararia… in Clinical and Translational Oncology (2021)

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  3. Article

    Open Access

    R0 resection following chemo (radio)therapy improves survival of primary inoperable pancreatic cancer patients. Interim results of the German randomized CONKO-007± trial

    Chemotherapy with or without radiotherapy is the standard in patients with initially nonmetastatic unresectable pancreatic cancer. Additional surgery is in discussion. The CONKO-007 multicenter randomized tria...

    Prof. Dr. R. Fietkau, R. Grützmann, U. A. Wittel… in Strahlentherapie und Onkologie (2021)

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  4. No Access

    Article

    Biodistribution and first clinical results of 18F-SiFAlin-TATE PET: a novel 18F-labeled somatostatin analog for imaging of neuroendocrine tumors

    PET/CT using 68Ga-labeled somatostatin analogs (SSA) targeting somatostatin receptors (SSR) on the cell surface of well-differentiated neuroendocrine tumors (NET) represents the clinical reference standard for im...

    Harun Ilhan, S. Lindner, A. Todica… in European Journal of Nuclear Medicine and M… (2020)

  5. No Access

    Article

    Neurotrophic tropomyosin receptor kinase (NTRK) and nerve growth factor (NGF) are not expressed in Caucasian patients with biliary tract cancers: pooled data from three independent cohorts

    Neuronal signaling has been implicated in the pathophysiology of multiple malignancies. In biliary tract cancers (BTCs), tumor cell expression of nerve growth factor (NGF) and its receptor neurotrophic tropomy...

    C. B. Westphalen, A. Preinfalk, S. Kruger, M. Haas… in Clinical and Translational Oncology (2019)

  6. Article

    Open Access

    Left-sided primary tumors are associated with favorable prognosis in patients with KRAS codon 12/13 wild-type metastatic colorectal cancer treated with cetuximab plus chemotherapy: an analysis of the AIO KRK-0104 trial

    AIO KRK-0104 investigated first-line therapy of metastatic colorectal cancer (mCRC) with cetuximab, capecitabine and irinotecan versus cetuximab, capecitabine and oxaliplatin. This analysis investigated the im...

    J. C. von Einem, V. Heinemann… in Journal of Cancer Research and Clinical On… (2014)

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  7. No Access

    Article

    Kinetics of dendritic cell chimerism and T cell chimerism in allogeneic hematopoietic stem cell recipients

    Dendritic cells (DC) as potent antigen-presenting cells (APC) and T cells as effector cells play an essential role in the pathophysiology of both graft-versus-host (GvH) and graft-versus-leukemia (GvL) reactio...

    S Boeck, M Hamann, V Pihusch, T Heller, H Diem, B Rolf… in Bone Marrow Transplantation (2006)