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Article
Open AccessLocalized fine-tuning and clinical evaluation of deep-learning based auto-segmentation (DLAS) model for clinical target volume (CTV) and organs-at-risk (OAR) in rectal cancer radiotherapy
Various deep learning auto-segmentation (DLAS) models have been proposed, some of which have been commercialized. However, the issue of performance degradation is notable when pretrained models are deployed in...
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Article
Multi-omics portrait of ductal carcinoma in situ in young women
Young patients with breast ductal carcinoma in situ (DCIS) often face a poorer prognosis. The genomic intricacies in young-onset DCIS, however, remain underexplored.
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Article
Autistic and Non-autistic Children’s Pain Perception is Modulated by Their First-Hand Pain Sensitivity and Theory of Mind
The current study examined whether autistic children’s perception of others’ pain could be modulated by their first-hand pain sensitivity and theory of mind (ToM). We measured the first-hand pain sensitivity, ...
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Article
ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs
Bidirectional transcription of mammalian mitochondrial DNA generates overlap** transcripts that are capable of forming double-stranded RNA (dsRNA) structures. Release of mitochondrial dsRNA into the cytosol ...
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Article
Open AccessComparison of anaesthesia strategies on postoperative nausea and vomiting in laparoscopic sleeve gastrectomy: a randomised controlled trial
Intra-operative anaesthesia management should be optimised to reduce the occurrence of postoperative nausea and vomiting in high-risk patients; however, a single intervention may not effectively reduce postope...
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Article
Open AccessPyrotinib and trastuzumab plus palbociclib and fulvestrant in HR+/HER2+ breast cancer patients with brain metastasis
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients are at a high risk of develo** metastases in the brain. However, research focusing on treatment strategies for hormonal r...
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Article
Photosynthesis and stress response of coal fly ash on stem elongation in wheat
Coal is one of the primary energy sources in China and is widely used for electricity generation. Crops growing in overlapped areas of farmland and coal resources (OAFCR) suffer from coal fly ash stress, espec...
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Article
Open AccessSize-dependent enhancement of gene expression by Plasmodium 5’UTR introns
Eukaryotic genes contain introns that are removed by the spliceosomal machinery during mRNA maturation. Introns impose a huge energetic burden on a cell; therefore, they must play an essential role in maintain...
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Article
Open AccessDeep learning implementation of image segmentation in agricultural applications: a comprehensive review
Image segmentation is a crucial task in computer vision, which divides a digital image into multiple segments and objects. In agriculture, image segmentation is extensively used for crop and soil monitoring, p...
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Article
Open AccessHow peer relationships affect academic achievement among junior high school students: The chain mediating roles of learning motivation and learning engagement
Despite the recognition of the impact of peer relationships, learning motivation, and learning engagement on academic achievement, there is still a gap in understanding the specific mechanisms through which pe...
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Article
Open AccessDevelopment of an interpretable machine learning model associated with genetic indicators to identify Yin-deficiency constitution
Traditional Chinese Medicine (TCM) defines constitutions which are relevant to corresponding diseases among people. As one of the common constitutions, Yin-deficiency constitution influences a number of Chinese p...
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Article
Correction: Toxic effects of atmospheric deposition in mining areas on wheat seedlings
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Open AccessCorrection: Community-based integrated care for patients with diabetes and depression (CIC-PDD): study protocol for a cluster randomized controlled trial
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Article
A MYB transcription factor GhTT2 of Gossypium hirsutum regulates proanthocyanidin accumulation and improves osmotic tolerance in Arabidopsis
Several MYB transcription factors have been identified as the regulators of proanthocyanidin biosynthesis in plants. However, limited research has been conducted on the functional characterization of MYBs invo...
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Article
Open AccessAbnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency
Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD). We aimed to characterise computed tomography (CT), spiro...
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Article
CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study
Controversial data have been reported on the prognostic value of C-X-C motif chemokine receptor 4 (CXCR4) in chronic lymphocytic leukemia (CLL). This prospective, single-center, observational study aimed to ev...
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Article
Open AccessSimulating photosynthetic energy transport on a photonic network
Quantum effects in photosynthetic energy transport in nature, especially for the typical Fenna-Matthews-Olson (FMO) complexes, are extensively studied in quantum biology. Such energy transport processes can be...
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Article
Open AccessDistinct correlation network of clinical characteristics in suicide attempters having adolescent major depressive disorder with non-suicidal self-injury
Suicidal behavior and non-suicidal self-injury (NSSI) are common in adolescent patients with major depressive disorder (MDD). Thus, delineating the unique characteristics of suicide attempters having adolescen...
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Article
Open AccessArachidonic acid inhibit granulosa cell function by affecting metabolic function of liver in brown adipose transplantation rats
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease and could be considered a metabolic disease because it is often accompanied by obesity and insulin resistance. Brown adipose tissue (BAT) t...
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Article
Toxic effects of atmospheric deposition in mining areas on wheat seedlings
Storage and transportation of coal, as well as operation of coal-fired power plants, produce amounts of metallic exhaust that may lead to different atmospheric environment in the overlapped areas of farmland a...
