19 Result(s)
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Article
TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC
TRAF-interacting protein (TRAIP), an E3 ligase containing a RING domain, has emerged as a significant contributor to maintaining genome integrity and is closely associated with cancer. Our study reveals that T...
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Article
Open AccessDevelopment and application of Chinese medical ontology for diabetes mellitus
To develop a Chinese Diabetes Mellitus Ontology (CDMO) and explore methods for constructing high-quality Chinese biomedical ontologies.
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Article
Open AccessContextualizing the revised Patient Perception of Patient-Centeredness (PPPC-R) scale in primary healthcare settings: a validity and reliability evaluation study
An English version of the Patient Perception of Patient-Centeredness (PPPC) scale was recently revised, and it is necessary to test this instrument in different primary care populations.
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Article
Dry eye syndrome: comprehensive etiologies and recent clinical trials
Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. ...
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Article
Development of SSR and SNP markers for identifying opium poppy
Papaver somniferum L. (opium poppy) is the original plant of heroin, which is a major narcotic drug, and this plant has brought great harm to human health. However, the ban on opium poppy cultivation and traffick...
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Article
Open AccessKetone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway
Ketone body β-hydroxybutyrate (BHB) has received more and more attentions, because it possesses a lot of beneficial, life-preserving effects in the fields of clinical science and medicine. However, the role of...
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Article
Integrated multi-omics profiling of nonfunctioning pituitary adenomas
Genetic and epigenetic alterations are involved in pituitary adenoma pathogenesis, however the molecular basis of proliferative nonfunctioning pituitary adenomas (NFPAs) remains unclear. Here, we analyzed inte...
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Article
A novel DNA damage response signature of IDH-mutant grade II and grade III astrocytoma at transcriptional level
The WHO classification for IDH-mutant grade II and grade III astrocytoma may not be as prognostically meaningful as expected. We aimed to develop a novel classification system based on the DNA damage response ...
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Article
Digital PCR-Based Detection of EGFR Mutations in Paired Plasma and CSF Samples of Lung Adenocarcinoma Patients with Central Nervous System Metastases
The presence of specific mutations in the EGFR gene informs the clinical pathway of therapy for patients with lung adenocarcinoma (LAC), including those with central nervous system (CNS) metastases. Plasma circul...
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Article
Open AccessThe correlation and prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death-ligand 1 (sPD-L1) in patients with hepatocellular carcinoma
Blocking the programmed death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway in hepatocellular carcinoma (HCC) is a very promising approach in immunotherapy. However, the correlation and prognostic...
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Article
A novel gene signature based on five glioblastoma stem-like cell relevant genes predicts the survival of primary glioblastoma
Primary glioblastoma (pGBM) is the most common and lethal type of neoplasms in the central nervous system, while the existing biomarkers, lacking consideration on the stemness changes of GBM cells, are not spe...
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Article
High probability and frequency of EGFR mutations in non-small cell lung cancer with brain metastases
Lung cancer is the leading cause of cancer death in men and women worldwide. Brain metastasis (BMs) of non-small cell lung cancer (NSCLC) is the most important cause of death. This study aimed to explore the a...
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Article
Pretreatment of Shaoyao Gancao Decoction (芍药甘草汤) alters pharmacokinetics of intravenous paclitaxel in rats
To investigate the effect of Shaoyao Gancao Decoction (芍药甘草汤, SGD) on the pharmacokinetics of intravenously administered paclitaxel in rats.
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Article
Paclitaxel plus platinum or gemcitabine plus platinum in first-line treatment of advanced non-small-cell lung cancer: results from 6 randomized controlled trials
The aim was to compare the efficacy and toxicity of paclitaxel plus platinum (TP) with gemcitabine plus platinum (GP) in untreated advanced non-small-cell lung cancer by a meta-analysis.
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Article
Brain metastases as the first symptom of lung cancer: a clinical study from an Asian medical center
Brain metastasis as the first symptom of lung cancer is a unique clinical entity. We conducted a retrospective study to investigate the clinical characteristics and survival of patients with lung cancer whose ...
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Article
Non-platinum doublets were as effective as platinum-based doublets for chemotherapy-naïve advanced non-small-cell lung cancer in the era of third-generation agents
The aim was to compare the efficacy between doublets of third-generation agents (non-platinum) and doublets of platinum plus a third-generation agent (platinum-based) for chemotherapy-naïve advanced non-small-...
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Article
A study of patients with brain metastases as the initial manifestation of their systemic cancer in a Chinese population
To investigate the clinical characteristics of patients with brain metastases as the initial manifestation of their systemic cancer in a Chinese population, a retrospective study of 254 such patients admitted ...
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Protocol
Enhanced Protein Profiling Arrays for Quantitative Measurement of Protein Expression in Multiple Samples
Simultaneous measurement of molecules from many samples is particularly useful for screening of certain molecules from different samples, for targeting verification of results obtained from protein and cDNA ar...
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Article
Diagnosis of Atypical Kawasaki Diseases in Early Stage by Echocardiography
Objective: To improve the diagnostic ability of atypical Kawasaki Diseases in early stage. Methods: Two-dimensional echocardiographic features of 24 cases with atypical Kawasaki disease in last two years were ...
