4 Result(s)
within
Robert T. Manguso
Immunology
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Article
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune chec...
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Article
Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fu...
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Chapter
Enhancing the Efficacy of Checkpoint Blockade Through Combination Therapies
Antibodies targeting coinhibitory receptors on T cells (“checkpoint blockade”) have emerged as some of the most promising therapies for a broad range of malignancies, including melanoma, non-small cell lung ca...
